T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by hepatic accumulation of excess lipids. T cells are commonly classified into various subsets based on their surface markers including T cell receptors, type of antigen presentation and pathophysiological functions. Several studi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoseph Asmelash Gebru, Haripriya Gupta, Hyeong Seop Kim, Jung A. Eom, Goo Hyun Kwon, Eunju Park, Jin-Ju Jeong, Sung-Min Won, Satya Priya Sharma, Raja Ganesan, Dong Joon Kim, Ki Tae Suk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antigen presenting cell T cells NK cells MHC I MHC II nonalcoholic fatty liver disease Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/03391aa5140c45bba3a38777058d1c70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03391aa5140c45bba3a38777058d1c70
record_format	dspace
spelling	oai:doaj.org-article:03391aa5140c45bba3a38777058d1c702021-11-25T17:54:10ZT Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease10.3390/ijms2222121901422-00671661-6596https://doaj.org/article/03391aa5140c45bba3a38777058d1c702021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12190https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by hepatic accumulation of excess lipids. T cells are commonly classified into various subsets based on their surface markers including T cell receptors, type of antigen presentation and pathophysiological functions. Several studies have implicated various T cell subsets and natural killer (NK) cells in the progression of NAFLD. While NK cells are mainly components of the innate hepatic immune system, the majority of T cell subsets can be part of both the adaptive and innate systems. Several studies have reported that various stages of NAFLD are accompanied by the accumulation of distinct T cell subsets and NK cells with different functions and phenotypes observed usually resulting in proinflammatory effects. More importantly, the overall stimulation of the intrahepatic T cell subsets is directly influenced by the homeostasis of the gut microbiota. Similarly, NK cells have been found to accumulate in the liver in response to pathogens and tumors. In this review, we discussed the nature and pathophysiological roles of T cell subsets including γδ T cells, NKT cells, Mucosal-associated invariant T (MAIT) cells as well as NK cells in NAFLD.Yoseph Asmelash GebruHaripriya GuptaHyeong Seop KimJung A. EomGoo Hyun KwonEunju ParkJin-Ju JeongSung-Min WonSatya Priya SharmaRaja GanesanDong Joon KimKi Tae SukMDPI AGarticleantigen presenting cellT cellsNK cellsMHC IMHC IInonalcoholic fatty liver diseaseBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12190, p 12190 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antigen presenting cell T cells NK cells MHC I MHC II nonalcoholic fatty liver disease Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	antigen presenting cell T cells NK cells MHC I MHC II nonalcoholic fatty liver disease Biology (General) QH301-705.5 Chemistry QD1-999 Yoseph Asmelash Gebru Haripriya Gupta Hyeong Seop Kim Jung A. Eom Goo Hyun Kwon Eunju Park Jin-Ju Jeong Sung-Min Won Satya Priya Sharma Raja Ganesan Dong Joon Kim Ki Tae Suk T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease
description	Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by hepatic accumulation of excess lipids. T cells are commonly classified into various subsets based on their surface markers including T cell receptors, type of antigen presentation and pathophysiological functions. Several studies have implicated various T cell subsets and natural killer (NK) cells in the progression of NAFLD. While NK cells are mainly components of the innate hepatic immune system, the majority of T cell subsets can be part of both the adaptive and innate systems. Several studies have reported that various stages of NAFLD are accompanied by the accumulation of distinct T cell subsets and NK cells with different functions and phenotypes observed usually resulting in proinflammatory effects. More importantly, the overall stimulation of the intrahepatic T cell subsets is directly influenced by the homeostasis of the gut microbiota. Similarly, NK cells have been found to accumulate in the liver in response to pathogens and tumors. In this review, we discussed the nature and pathophysiological roles of T cell subsets including γδ T cells, NKT cells, Mucosal-associated invariant T (MAIT) cells as well as NK cells in NAFLD.
format	article
author	Yoseph Asmelash Gebru Haripriya Gupta Hyeong Seop Kim Jung A. Eom Goo Hyun Kwon Eunju Park Jin-Ju Jeong Sung-Min Won Satya Priya Sharma Raja Ganesan Dong Joon Kim Ki Tae Suk
author_facet	Yoseph Asmelash Gebru Haripriya Gupta Hyeong Seop Kim Jung A. Eom Goo Hyun Kwon Eunju Park Jin-Ju Jeong Sung-Min Won Satya Priya Sharma Raja Ganesan Dong Joon Kim Ki Tae Suk
author_sort	Yoseph Asmelash Gebru
title	T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_short	T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_full	T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_fullStr	T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_full_unstemmed	T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease
title_sort	t cell subsets and natural killer cells in the pathogenesis of nonalcoholic fatty liver disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/03391aa5140c45bba3a38777058d1c70
work_keys_str_mv	AT yosephasmelashgebru tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT haripriyagupta tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT hyeongseopkim tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT jungaeom tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT goohyunkwon tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT eunjupark tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT jinjujeong tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT sungminwon tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT satyapriyasharma tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT rajaganesan tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT dongjoonkim tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease AT kitaesuk tcellsubsetsandnaturalkillercellsinthepathogenesisofnonalcoholicfattyliverdisease
_version_	1718411841511620608

T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Ejemplares similares