Shape effect of cerium oxide nanoparticles on mild traumatic brain injury

Abstract The catalytic performance and therapeutic effect of nanoparticles varies with shape. Here, we investigated and compared the therapeutic outcomes of ceria nanospheres (Ceria NSs) and ceria nanorods (Ceria NRs) in an in vivo study of mild traumatic brain injury (mTBI). In vivo TBI was induced...

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Autores principales:	Dong Hyuk Youn, Ngoc Minh Tran, Bong Jun Kim, Youngmi Kim, Jin Pyeong Jeon, Hyojong Yoo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03395ed1143c4606955c5d68fef02b7e
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spelling	oai:doaj.org-article:03395ed1143c4606955c5d68fef02b7e2021-12-02T16:06:43ZShape effect of cerium oxide nanoparticles on mild traumatic brain injury10.1038/s41598-021-95057-92045-2322https://doaj.org/article/03395ed1143c4606955c5d68fef02b7e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95057-9https://doaj.org/toc/2045-2322Abstract The catalytic performance and therapeutic effect of nanoparticles varies with shape. Here, we investigated and compared the therapeutic outcomes of ceria nanospheres (Ceria NSs) and ceria nanorods (Ceria NRs) in an in vivo study of mild traumatic brain injury (mTBI). In vivo TBI was induced in a mouse model of open head injury using a stereotaxic impactor. Outcomes including cytoprotective effects, cognitive function, and cerebral edema were investigated after retro-orbital injection of 11.6 mM of ceria nanoparticles. Ceria nanoparticles significantly reduced fluoro-jade B (FJB)-positive cells and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells, and restored mRNA levels of superoxide dismutase 1 (SOD1) and SOD2. They also decreased the cyclooxygenase-2 (COX-2) expression compared with the untreated control group. Comparing the two nanomaterials, Ceria NRs showed less stable and high-energy (100) and (110) planes, which increased the number of active sites. The Ce3+/Ce4+ molar ratio of Ceria NRs (0.40) was greater than that of Ceria NSs (0.27). Ceria NRs (0.059 ± 0.021) appeared to exhibit better anti-inflammatory effect than Ceria NSs (0.133 ± 0.024), but the effect was statistically insignificant (p = 0.190). Ceria nanoparticles also improved cognitive impairment following mTBI compared with the control group, but the effect did not differ significantly according to the nanoshape. However, Ceria NRs (70.1 ± 0.5%) significantly decreased brain water content compared with Ceria NSs (73.7 ± 0.4%; p = 0.0015), indicating a more effective reduction in brain edema (p = 0.0015). Compared with Ceria NSs, the Ceria NRs are more effective in alleviating cerebral edema following in vivo mTBI.Dong Hyuk YounNgoc Minh TranBong Jun KimYoungmi KimJin Pyeong JeonHyojong YooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Hyuk Youn Ngoc Minh Tran Bong Jun Kim Youngmi Kim Jin Pyeong Jeon Hyojong Yoo Shape effect of cerium oxide nanoparticles on mild traumatic brain injury
description	Abstract The catalytic performance and therapeutic effect of nanoparticles varies with shape. Here, we investigated and compared the therapeutic outcomes of ceria nanospheres (Ceria NSs) and ceria nanorods (Ceria NRs) in an in vivo study of mild traumatic brain injury (mTBI). In vivo TBI was induced in a mouse model of open head injury using a stereotaxic impactor. Outcomes including cytoprotective effects, cognitive function, and cerebral edema were investigated after retro-orbital injection of 11.6 mM of ceria nanoparticles. Ceria nanoparticles significantly reduced fluoro-jade B (FJB)-positive cells and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells, and restored mRNA levels of superoxide dismutase 1 (SOD1) and SOD2. They also decreased the cyclooxygenase-2 (COX-2) expression compared with the untreated control group. Comparing the two nanomaterials, Ceria NRs showed less stable and high-energy (100) and (110) planes, which increased the number of active sites. The Ce3+/Ce4+ molar ratio of Ceria NRs (0.40) was greater than that of Ceria NSs (0.27). Ceria NRs (0.059 ± 0.021) appeared to exhibit better anti-inflammatory effect than Ceria NSs (0.133 ± 0.024), but the effect was statistically insignificant (p = 0.190). Ceria nanoparticles also improved cognitive impairment following mTBI compared with the control group, but the effect did not differ significantly according to the nanoshape. However, Ceria NRs (70.1 ± 0.5%) significantly decreased brain water content compared with Ceria NSs (73.7 ± 0.4%; p = 0.0015), indicating a more effective reduction in brain edema (p = 0.0015). Compared with Ceria NSs, the Ceria NRs are more effective in alleviating cerebral edema following in vivo mTBI.
format	article
author	Dong Hyuk Youn Ngoc Minh Tran Bong Jun Kim Youngmi Kim Jin Pyeong Jeon Hyojong Yoo
author_facet	Dong Hyuk Youn Ngoc Minh Tran Bong Jun Kim Youngmi Kim Jin Pyeong Jeon Hyojong Yoo
author_sort	Dong Hyuk Youn
title	Shape effect of cerium oxide nanoparticles on mild traumatic brain injury
title_short	Shape effect of cerium oxide nanoparticles on mild traumatic brain injury
title_full	Shape effect of cerium oxide nanoparticles on mild traumatic brain injury
title_fullStr	Shape effect of cerium oxide nanoparticles on mild traumatic brain injury
title_full_unstemmed	Shape effect of cerium oxide nanoparticles on mild traumatic brain injury
title_sort	shape effect of cerium oxide nanoparticles on mild traumatic brain injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/03395ed1143c4606955c5d68fef02b7e
work_keys_str_mv	AT donghyukyoun shapeeffectofceriumoxidenanoparticlesonmildtraumaticbraininjury AT ngocminhtran shapeeffectofceriumoxidenanoparticlesonmildtraumaticbraininjury AT bongjunkim shapeeffectofceriumoxidenanoparticlesonmildtraumaticbraininjury AT youngmikim shapeeffectofceriumoxidenanoparticlesonmildtraumaticbraininjury AT jinpyeongjeon shapeeffectofceriumoxidenanoparticlesonmildtraumaticbraininjury AT hyojongyoo shapeeffectofceriumoxidenanoparticlesonmildtraumaticbraininjury
_version_	1718384882560794624

Shape effect of cerium oxide nanoparticles on mild traumatic brain injury

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