Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis

Osteomicrobiology is a new research field in which the aim is to explore the role of microbiota in bone homeostasis. The alveolar bone is that part of the maxilla and mandible that supports the teeth. It is now evident that naturally occurring alveolar bone loss is considerably stunted in germ-free...

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Autores principales:	Xingqun Cheng, Xuedong Zhou, Chengcheng Liu, Xin Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	oral microbiota alveolar bone osteomicrobiology osteoimmunology RANKL signaling Notch signaling Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/033a0f49967c44e0b5cdfe540b5fb1bb
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spelling	oai:doaj.org-article:033a0f49967c44e0b5cdfe540b5fb1bb2021-11-17T05:41:02ZOral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis2235-298810.3389/fcimb.2021.751503https://doaj.org/article/033a0f49967c44e0b5cdfe540b5fb1bb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.751503/fullhttps://doaj.org/toc/2235-2988Osteomicrobiology is a new research field in which the aim is to explore the role of microbiota in bone homeostasis. The alveolar bone is that part of the maxilla and mandible that supports the teeth. It is now evident that naturally occurring alveolar bone loss is considerably stunted in germ-free mice compared with specific-pathogen-free mice. Recently, the roles of oral microbiota in modulating host defense systems and alveolar bone homeostasis have attracted increasing attention. Moreover, the mechanistic understanding of oral microbiota in mediating alveolar bone remodeling processes is undergoing rapid progress due to the advancement in technology. In this review, to provide insight into the role of oral microbiota in alveolar bone homeostasis, we introduced the term “oral osteomicrobiology.” We discussed regulation of alveolar bone development and bone loss by oral microbiota under physiological and pathological conditions. We also focused on the signaling pathways involved in oral osteomicrobiology and discussed the bridging role of osteoimmunity and influencing factors in this process. Finally, the critical techniques for osteomicrobiological investigations were introduced.Xingqun ChengXuedong ZhouChengcheng LiuXin XuFrontiers Media S.A.articleoral microbiotaalveolar boneosteomicrobiologyosteoimmunologyRANKL signalingNotch signalingMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral microbiota alveolar bone osteomicrobiology osteoimmunology RANKL signaling Notch signaling Microbiology QR1-502
spellingShingle	oral microbiota alveolar bone osteomicrobiology osteoimmunology RANKL signaling Notch signaling Microbiology QR1-502 Xingqun Cheng Xuedong Zhou Chengcheng Liu Xin Xu Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
description	Osteomicrobiology is a new research field in which the aim is to explore the role of microbiota in bone homeostasis. The alveolar bone is that part of the maxilla and mandible that supports the teeth. It is now evident that naturally occurring alveolar bone loss is considerably stunted in germ-free mice compared with specific-pathogen-free mice. Recently, the roles of oral microbiota in modulating host defense systems and alveolar bone homeostasis have attracted increasing attention. Moreover, the mechanistic understanding of oral microbiota in mediating alveolar bone remodeling processes is undergoing rapid progress due to the advancement in technology. In this review, to provide insight into the role of oral microbiota in alveolar bone homeostasis, we introduced the term “oral osteomicrobiology.” We discussed regulation of alveolar bone development and bone loss by oral microbiota under physiological and pathological conditions. We also focused on the signaling pathways involved in oral osteomicrobiology and discussed the bridging role of osteoimmunity and influencing factors in this process. Finally, the critical techniques for osteomicrobiological investigations were introduced.
format	article
author	Xingqun Cheng Xuedong Zhou Chengcheng Liu Xin Xu
author_facet	Xingqun Cheng Xuedong Zhou Chengcheng Liu Xin Xu
author_sort	Xingqun Cheng
title	Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_short	Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_full	Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_fullStr	Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_full_unstemmed	Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_sort	oral osteomicrobiology: the role of oral microbiota in alveolar bone homeostasis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/033a0f49967c44e0b5cdfe540b5fb1bb
work_keys_str_mv	AT xingquncheng oralosteomicrobiologytheroleoforalmicrobiotainalveolarbonehomeostasis AT xuedongzhou oralosteomicrobiologytheroleoforalmicrobiotainalveolarbonehomeostasis AT chengchengliu oralosteomicrobiologytheroleoforalmicrobiotainalveolarbonehomeostasis AT xinxu oralosteomicrobiologytheroleoforalmicrobiotainalveolarbonehomeostasis
_version_	1718425842691866624

Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis

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