Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that urocortin-3 (Ucn3)-expressing neurons in the hypothalamic perif...

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Autores principales:	Anita E Autry, Zheng Wu, Vikrant Kapoor, Johannes Kohl, Dhananjay Bambah-Mukku, Nimrod D Rubinstein, Brenda Marin-Rodriguez, Ilaria Carta, Victoria Sedwick, Ming Tang, Catherine Dulac
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	parenting aggression neuronal circuits social behavior infanticide hypothalamus Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/033c306675694fa58312763ea717d719
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spelling	oai:doaj.org-article:033c306675694fa58312763ea717d7192021-11-15T07:03:15ZUrocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression10.7554/eLife.646802050-084Xe64680https://doaj.org/article/033c306675694fa58312763ea717d7192021-08-01T00:00:00Zhttps://elifesciences.org/articles/64680https://doaj.org/toc/2050-084XWhile recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that urocortin-3 (Ucn3)-expressing neurons in the hypothalamic perifornical area (PeFAUcn3) are activated during infant-directed attacks in males and females, but not other behaviors. Functional manipulations of PeFAUcn3 neurons demonstrate the role of this population in the negative control of parenting in both sexes. PeFAUcn3 neurons receive input from areas associated with vomeronasal sensing, stress, and parenting, and send projections to hypothalamic and limbic areas. Optogenetic activation of PeFAUcn3 axon terminals in these regions triggers various aspects of infant-directed agonistic responses, such as neglect, repulsion, and aggression. Thus, PeFAUcn3 neurons emerge as a dedicated circuit component controlling infant-directed neglect and aggression, providing a new framework to understand the positive and negative regulation of parenting in health and disease.Anita E AutryZheng WuVikrant KapoorJohannes KohlDhananjay Bambah-MukkuNimrod D RubinsteinBrenda Marin-RodriguezIlaria CartaVictoria SedwickMing TangCatherine DulaceLife Sciences Publications Ltdarticleparentingaggressionneuronal circuitssocial behaviorinfanticidehypothalamusMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	parenting aggression neuronal circuits social behavior infanticide hypothalamus Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	parenting aggression neuronal circuits social behavior infanticide hypothalamus Medicine R Science Q Biology (General) QH301-705.5 Anita E Autry Zheng Wu Vikrant Kapoor Johannes Kohl Dhananjay Bambah-Mukku Nimrod D Rubinstein Brenda Marin-Rodriguez Ilaria Carta Victoria Sedwick Ming Tang Catherine Dulac Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
description	While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that urocortin-3 (Ucn3)-expressing neurons in the hypothalamic perifornical area (PeFAUcn3) are activated during infant-directed attacks in males and females, but not other behaviors. Functional manipulations of PeFAUcn3 neurons demonstrate the role of this population in the negative control of parenting in both sexes. PeFAUcn3 neurons receive input from areas associated with vomeronasal sensing, stress, and parenting, and send projections to hypothalamic and limbic areas. Optogenetic activation of PeFAUcn3 axon terminals in these regions triggers various aspects of infant-directed agonistic responses, such as neglect, repulsion, and aggression. Thus, PeFAUcn3 neurons emerge as a dedicated circuit component controlling infant-directed neglect and aggression, providing a new framework to understand the positive and negative regulation of parenting in health and disease.
format	article
author	Anita E Autry Zheng Wu Vikrant Kapoor Johannes Kohl Dhananjay Bambah-Mukku Nimrod D Rubinstein Brenda Marin-Rodriguez Ilaria Carta Victoria Sedwick Ming Tang Catherine Dulac
author_facet	Anita E Autry Zheng Wu Vikrant Kapoor Johannes Kohl Dhananjay Bambah-Mukku Nimrod D Rubinstein Brenda Marin-Rodriguez Ilaria Carta Victoria Sedwick Ming Tang Catherine Dulac
author_sort	Anita E Autry
title	Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
title_short	Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
title_full	Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
title_fullStr	Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
title_full_unstemmed	Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
title_sort	urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/033c306675694fa58312763ea717d719
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Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

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