Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space

Abstract The differential impact of complete and incomplete bilateral vestibulopathy (BVP) on spatial orientation, visual exploration, and navigation-induced brain network activations is still under debate. In this study, 14 BVP patients (6 complete, 8 incomplete) and 14 age-matched healthy controls...

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Autores principales:	Florian Schöberl, Cauchy Pradhan, Maximilian Grosch, Matthias Brendel, Florian Jostes, Katrin Obermaier, Chantal Sowa, Klaus Jahn, Peter Bartenstein, Thomas Brandt, Marianne Dieterich, Andreas Zwergal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/034260c7c82a45ff88090b0eb36c22fb
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spelling	oai:doaj.org-article:034260c7c82a45ff88090b0eb36c22fb2021-12-02T13:57:26ZBilateral vestibulopathy causes selective deficits in recombining novel routes in real space10.1038/s41598-021-82427-62045-2322https://doaj.org/article/034260c7c82a45ff88090b0eb36c22fb2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82427-6https://doaj.org/toc/2045-2322Abstract The differential impact of complete and incomplete bilateral vestibulopathy (BVP) on spatial orientation, visual exploration, and navigation-induced brain network activations is still under debate. In this study, 14 BVP patients (6 complete, 8 incomplete) and 14 age-matched healthy controls performed a navigation task requiring them to retrace familiar routes and recombine novel routes to find five items in real space. [18F]-fluorodeoxyglucose-PET was used to determine navigation-induced brain activations. Participants wore a gaze-controlled, head-fixed camera that recorded their visual exploration behaviour. Patients performed worse, when recombining novel routes (p < 0.001), whereas retracing of familiar routes was normal (p = 0.82). These deficits correlated with the severity of BVP. Patients exhibited higher gait fluctuations, spent less time at crossroads, and used a possible shortcut less often (p < 0.05). The right hippocampus and entorhinal cortex were less active and the bilateral parahippocampal place area more active during navigation in patients. Complete BVP showed reduced activations in the pontine brainstem, anterior thalamus, posterior insular, and retrosplenial cortex compared to incomplete BVP. The navigation-induced brain activation pattern in BVP is compatible with deficits in creating a mental representation of a novel environment. Residual vestibular function allows recruitment of brain areas involved in head direction signalling to support navigation.Florian SchöberlCauchy PradhanMaximilian GroschMatthias BrendelFlorian JostesKatrin ObermaierChantal SowaKlaus JahnPeter BartensteinThomas BrandtMarianne DieterichAndreas ZwergalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Florian Schöberl Cauchy Pradhan Maximilian Grosch Matthias Brendel Florian Jostes Katrin Obermaier Chantal Sowa Klaus Jahn Peter Bartenstein Thomas Brandt Marianne Dieterich Andreas Zwergal Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space
description	Abstract The differential impact of complete and incomplete bilateral vestibulopathy (BVP) on spatial orientation, visual exploration, and navigation-induced brain network activations is still under debate. In this study, 14 BVP patients (6 complete, 8 incomplete) and 14 age-matched healthy controls performed a navigation task requiring them to retrace familiar routes and recombine novel routes to find five items in real space. [18F]-fluorodeoxyglucose-PET was used to determine navigation-induced brain activations. Participants wore a gaze-controlled, head-fixed camera that recorded their visual exploration behaviour. Patients performed worse, when recombining novel routes (p < 0.001), whereas retracing of familiar routes was normal (p = 0.82). These deficits correlated with the severity of BVP. Patients exhibited higher gait fluctuations, spent less time at crossroads, and used a possible shortcut less often (p < 0.05). The right hippocampus and entorhinal cortex were less active and the bilateral parahippocampal place area more active during navigation in patients. Complete BVP showed reduced activations in the pontine brainstem, anterior thalamus, posterior insular, and retrosplenial cortex compared to incomplete BVP. The navigation-induced brain activation pattern in BVP is compatible with deficits in creating a mental representation of a novel environment. Residual vestibular function allows recruitment of brain areas involved in head direction signalling to support navigation.
format	article
author	Florian Schöberl Cauchy Pradhan Maximilian Grosch Matthias Brendel Florian Jostes Katrin Obermaier Chantal Sowa Klaus Jahn Peter Bartenstein Thomas Brandt Marianne Dieterich Andreas Zwergal
author_facet	Florian Schöberl Cauchy Pradhan Maximilian Grosch Matthias Brendel Florian Jostes Katrin Obermaier Chantal Sowa Klaus Jahn Peter Bartenstein Thomas Brandt Marianne Dieterich Andreas Zwergal
author_sort	Florian Schöberl
title	Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space
title_short	Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space
title_full	Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space
title_fullStr	Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space
title_full_unstemmed	Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space
title_sort	bilateral vestibulopathy causes selective deficits in recombining novel routes in real space
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/034260c7c82a45ff88090b0eb36c22fb
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Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space

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