A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

Here, the authors provide a panel of medium-throughput assays to test potential drug candidates against different life cycle stages of Cryptosporidium with the goal to support a drug development pipeline that contains compounds with diverse molecular mechanisms of action.

Guardado en:

Detalles Bibliográficos
Autores principales:	Rajiv S. Jumani, Muhammad M. Hasan, Erin E. Stebbins, Liam Donnelly, Peter Miller, Connor Klopfer, Kovi Bessoff, Jose E. Teixeira, Melissa S. Love, Case W. McNamara, Christopher D. Huston
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03437c7266734301bb9d6a058e5a30f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03437c7266734301bb9d6a058e5a30f9
record_format	dspace
spelling	oai:doaj.org-article:03437c7266734301bb9d6a058e5a30f92021-12-02T14:38:59ZA suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors10.1038/s41467-019-09880-w2041-1723https://doaj.org/article/03437c7266734301bb9d6a058e5a30f92019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09880-whttps://doaj.org/toc/2041-1723Here, the authors provide a panel of medium-throughput assays to test potential drug candidates against different life cycle stages of Cryptosporidium with the goal to support a drug development pipeline that contains compounds with diverse molecular mechanisms of action.Rajiv S. JumaniMuhammad M. HasanErin E. StebbinsLiam DonnellyPeter MillerConnor KlopferKovi BessoffJose E. TeixeiraMelissa S. LoveCase W. McNamaraChristopher D. HustonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajiv S. Jumani Muhammad M. Hasan Erin E. Stebbins Liam Donnelly Peter Miller Connor Klopfer Kovi Bessoff Jose E. Teixeira Melissa S. Love Case W. McNamara Christopher D. Huston A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
description	Here, the authors provide a panel of medium-throughput assays to test potential drug candidates against different life cycle stages of Cryptosporidium with the goal to support a drug development pipeline that contains compounds with diverse molecular mechanisms of action.
format	article
author	Rajiv S. Jumani Muhammad M. Hasan Erin E. Stebbins Liam Donnelly Peter Miller Connor Klopfer Kovi Bessoff Jose E. Teixeira Melissa S. Love Case W. McNamara Christopher D. Huston
author_facet	Rajiv S. Jumani Muhammad M. Hasan Erin E. Stebbins Liam Donnelly Peter Miller Connor Klopfer Kovi Bessoff Jose E. Teixeira Melissa S. Love Case W. McNamara Christopher D. Huston
author_sort	Rajiv S. Jumani
title	A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
title_short	A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
title_full	A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
title_fullStr	A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
title_full_unstemmed	A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors
title_sort	suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like cryptosporidium growth inhibitors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/03437c7266734301bb9d6a058e5a30f9
work_keys_str_mv	AT rajivsjumani asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT muhammadmhasan asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT erinestebbins asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT liamdonnelly asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT petermiller asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT connorklopfer asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT kovibessoff asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT joseeteixeira asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT melissaslove asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT casewmcnamara asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT christopherdhuston asuiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT rajivsjumani suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT muhammadmhasan suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT erinestebbins suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT liamdonnelly suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT petermiller suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT connorklopfer suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT kovibessoff suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT joseeteixeira suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT melissaslove suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT casewmcnamara suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors AT christopherdhuston suiteofphenotypicassaystoensurepipelinediversitywhenprioritizingdruglikecryptosporidiumgrowthinhibitors
_version_	1718390752019480576

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

Ejemplares similares