Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms

Abstract There is a close relationship between the gut microbiota and metabolic disorders. In this study, acute administration of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide to mice increased the cecal levels of caseinolytic protease B, a component of Escherichia coli, and of...

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Autores principales:	Shunsuke Kato, Takehiro Sato, Hiroki Fujita, Masahiro Kawatani, Yuichiro Yamada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/034892e131b2485283cb845d9eb1d703
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spelling	oai:doaj.org-article:034892e131b2485283cb845d9eb1d7032021-12-02T17:16:17ZEffects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms10.1038/s41598-021-88612-x2045-2322https://doaj.org/article/034892e131b2485283cb845d9eb1d7032021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88612-xhttps://doaj.org/toc/2045-2322Abstract There is a close relationship between the gut microbiota and metabolic disorders. In this study, acute administration of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide to mice increased the cecal levels of caseinolytic protease B, a component of Escherichia coli, and of norepinephrine. Chemical sympathectomy blocked these events. Norepinephrine was found to pass into the intestinal lumen in vitro. c-Fos staining of the intermediolateral nucleus was identified as indirect evidence of sympathetic nervous system activation of the intestinal tract by GLP-1RA. Under normal conditions, the increase in E. coli did not affect the host. However, in mice with colitis, bacterial translocation was observed with attenuation of tight junction gene expression. This is the first study to investigate the unique underlying mechanisms related the effects of GLP-1RA on changes in the gut bacterium.Shunsuke KatoTakehiro SatoHiroki FujitaMasahiro KawataniYuichiro YamadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shunsuke Kato Takehiro Sato Hiroki Fujita Masahiro Kawatani Yuichiro Yamada Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms
description	Abstract There is a close relationship between the gut microbiota and metabolic disorders. In this study, acute administration of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide to mice increased the cecal levels of caseinolytic protease B, a component of Escherichia coli, and of norepinephrine. Chemical sympathectomy blocked these events. Norepinephrine was found to pass into the intestinal lumen in vitro. c-Fos staining of the intermediolateral nucleus was identified as indirect evidence of sympathetic nervous system activation of the intestinal tract by GLP-1RA. Under normal conditions, the increase in E. coli did not affect the host. However, in mice with colitis, bacterial translocation was observed with attenuation of tight junction gene expression. This is the first study to investigate the unique underlying mechanisms related the effects of GLP-1RA on changes in the gut bacterium.
format	article
author	Shunsuke Kato Takehiro Sato Hiroki Fujita Masahiro Kawatani Yuichiro Yamada
author_facet	Shunsuke Kato Takehiro Sato Hiroki Fujita Masahiro Kawatani Yuichiro Yamada
author_sort	Shunsuke Kato
title	Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms
title_short	Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms
title_full	Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms
title_fullStr	Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms
title_full_unstemmed	Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms
title_sort	effects of glp-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/034892e131b2485283cb845d9eb1d703
work_keys_str_mv	AT shunsukekato effectsofglp1receptoragonistonchangesinthegutbacteriumandtheunderlyingmechanisms AT takehirosato effectsofglp1receptoragonistonchangesinthegutbacteriumandtheunderlyingmechanisms AT hirokifujita effectsofglp1receptoragonistonchangesinthegutbacteriumandtheunderlyingmechanisms AT masahirokawatani effectsofglp1receptoragonistonchangesinthegutbacteriumandtheunderlyingmechanisms AT yuichiroyamada effectsofglp1receptoragonistonchangesinthegutbacteriumandtheunderlyingmechanisms
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Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms

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