Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report

Background: Trigeminal neuralgia can be classical or idiopathic. While trigeminal neuralgia (TN) due to space-occupying lesions is atypical, such lesions rarely cause severe TN secondary to trigeminal nerve irritation. Mass effect from these lesions has been shown to correlate with symptom burden, d...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Billie Hsieh, Barlas Benkli, George N Ansoanuur, Eliana E Bonfante-Mejia, Shaun O Smart
Formato: article
Lenguaje:EN
Publicado: SAGE Publishing 2021
Materias:
Acceso en línea:https://doaj.org/article/0348aa7110814480b7ba0e9b42d62084
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0348aa7110814480b7ba0e9b42d62084
record_format dspace
spelling oai:doaj.org-article:0348aa7110814480b7ba0e9b42d620842021-11-16T06:03:22ZLevetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report2515-816310.1177/25158163211042389https://doaj.org/article/0348aa7110814480b7ba0e9b42d620842021-08-01T00:00:00Zhttps://doi.org/10.1177/25158163211042389https://doaj.org/toc/2515-8163Background: Trigeminal neuralgia can be classical or idiopathic. While trigeminal neuralgia (TN) due to space-occupying lesions is atypical, such lesions rarely cause severe TN secondary to trigeminal nerve irritation. Mass effect from these lesions has been shown to correlate with symptom burden, due to direct or indirect compressive effects. A tethering effect, provoked by an abnormal root-stretching force, theoretically plays a role in trigeminal nerve hyperexcitability. Case: The likely etiology in this case presentation is a large glomus tumor invading the middle and posterior cranial fossa. Glomus tumors are uncommon benign tumors of the head and neck derived from neural crest cells. Even more strikingly, a large glomus tumor causes bilateral TN due to direct compression on one side and indirect compression on the contralateral side. Conclusion: Although the gold standard in TN management is carbamazepine, other anti-epileptic drugs (AEDs) have been used in the treatment of patients unable to take carbamazepine. A few studies suggest levetiracetam alleviates central and neuropathic pain, supporting the hypothesis that it may be effective in management of TN.Billie HsiehBarlas BenkliGeorge N AnsoanuurEliana E Bonfante-MejiaShaun O SmartSAGE PublishingarticleTherapeutics. PharmacologyRM1-950Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENCephalalgia Reports, Vol 4 (2021)
institution DOAJ
collection DOAJ
language EN
topic Therapeutics. Pharmacology
RM1-950
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle Therapeutics. Pharmacology
RM1-950
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Billie Hsieh
Barlas Benkli
George N Ansoanuur
Eliana E Bonfante-Mejia
Shaun O Smart
Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
description Background: Trigeminal neuralgia can be classical or idiopathic. While trigeminal neuralgia (TN) due to space-occupying lesions is atypical, such lesions rarely cause severe TN secondary to trigeminal nerve irritation. Mass effect from these lesions has been shown to correlate with symptom burden, due to direct or indirect compressive effects. A tethering effect, provoked by an abnormal root-stretching force, theoretically plays a role in trigeminal nerve hyperexcitability. Case: The likely etiology in this case presentation is a large glomus tumor invading the middle and posterior cranial fossa. Glomus tumors are uncommon benign tumors of the head and neck derived from neural crest cells. Even more strikingly, a large glomus tumor causes bilateral TN due to direct compression on one side and indirect compression on the contralateral side. Conclusion: Although the gold standard in TN management is carbamazepine, other anti-epileptic drugs (AEDs) have been used in the treatment of patients unable to take carbamazepine. A few studies suggest levetiracetam alleviates central and neuropathic pain, supporting the hypothesis that it may be effective in management of TN.
format article
author Billie Hsieh
Barlas Benkli
George N Ansoanuur
Eliana E Bonfante-Mejia
Shaun O Smart
author_facet Billie Hsieh
Barlas Benkli
George N Ansoanuur
Eliana E Bonfante-Mejia
Shaun O Smart
author_sort Billie Hsieh
title Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_short Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_full Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_fullStr Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_full_unstemmed Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_sort levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
publisher SAGE Publishing
publishDate 2021
url https://doaj.org/article/0348aa7110814480b7ba0e9b42d62084
work_keys_str_mv AT billiehsieh levetiracetaminmanagementofbilateraltrigeminalneuralgiaduetolargeglomustumorcasereport
AT barlasbenkli levetiracetaminmanagementofbilateraltrigeminalneuralgiaduetolargeglomustumorcasereport
AT georgenansoanuur levetiracetaminmanagementofbilateraltrigeminalneuralgiaduetolargeglomustumorcasereport
AT elianaebonfantemejia levetiracetaminmanagementofbilateraltrigeminalneuralgiaduetolargeglomustumorcasereport
AT shaunosmart levetiracetaminmanagementofbilateraltrigeminalneuralgiaduetolargeglomustumorcasereport
_version_ 1718426645127233536