Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report

Background: Trigeminal neuralgia can be classical or idiopathic. While trigeminal neuralgia (TN) due to space-occupying lesions is atypical, such lesions rarely cause severe TN secondary to trigeminal nerve irritation. Mass effect from these lesions has been shown to correlate with symptom burden, d...

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Autores principales:	Billie Hsieh, Barlas Benkli, George N Ansoanuur, Eliana E Bonfante-Mejia, Shaun O Smart
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Therapeutics. Pharmacology RM1-950 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/0348aa7110814480b7ba0e9b42d62084
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spelling	oai:doaj.org-article:0348aa7110814480b7ba0e9b42d620842021-11-16T06:03:22ZLevetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report2515-816310.1177/25158163211042389https://doaj.org/article/0348aa7110814480b7ba0e9b42d620842021-08-01T00:00:00Zhttps://doi.org/10.1177/25158163211042389https://doaj.org/toc/2515-8163Background: Trigeminal neuralgia can be classical or idiopathic. While trigeminal neuralgia (TN) due to space-occupying lesions is atypical, such lesions rarely cause severe TN secondary to trigeminal nerve irritation. Mass effect from these lesions has been shown to correlate with symptom burden, due to direct or indirect compressive effects. A tethering effect, provoked by an abnormal root-stretching force, theoretically plays a role in trigeminal nerve hyperexcitability. Case: The likely etiology in this case presentation is a large glomus tumor invading the middle and posterior cranial fossa. Glomus tumors are uncommon benign tumors of the head and neck derived from neural crest cells. Even more strikingly, a large glomus tumor causes bilateral TN due to direct compression on one side and indirect compression on the contralateral side. Conclusion: Although the gold standard in TN management is carbamazepine, other anti-epileptic drugs (AEDs) have been used in the treatment of patients unable to take carbamazepine. A few studies suggest levetiracetam alleviates central and neuropathic pain, supporting the hypothesis that it may be effective in management of TN.Billie HsiehBarlas BenkliGeorge N AnsoanuurEliana E Bonfante-MejiaShaun O SmartSAGE PublishingarticleTherapeutics. PharmacologyRM1-950Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENCephalalgia Reports, Vol 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Therapeutics. Pharmacology RM1-950 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Billie Hsieh Barlas Benkli George N Ansoanuur Eliana E Bonfante-Mejia Shaun O Smart Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
description	Background: Trigeminal neuralgia can be classical or idiopathic. While trigeminal neuralgia (TN) due to space-occupying lesions is atypical, such lesions rarely cause severe TN secondary to trigeminal nerve irritation. Mass effect from these lesions has been shown to correlate with symptom burden, due to direct or indirect compressive effects. A tethering effect, provoked by an abnormal root-stretching force, theoretically plays a role in trigeminal nerve hyperexcitability. Case: The likely etiology in this case presentation is a large glomus tumor invading the middle and posterior cranial fossa. Glomus tumors are uncommon benign tumors of the head and neck derived from neural crest cells. Even more strikingly, a large glomus tumor causes bilateral TN due to direct compression on one side and indirect compression on the contralateral side. Conclusion: Although the gold standard in TN management is carbamazepine, other anti-epileptic drugs (AEDs) have been used in the treatment of patients unable to take carbamazepine. A few studies suggest levetiracetam alleviates central and neuropathic pain, supporting the hypothesis that it may be effective in management of TN.
format	article
author	Billie Hsieh Barlas Benkli George N Ansoanuur Eliana E Bonfante-Mejia Shaun O Smart
author_facet	Billie Hsieh Barlas Benkli George N Ansoanuur Eliana E Bonfante-Mejia Shaun O Smart
author_sort	Billie Hsieh
title	Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_short	Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_full	Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_fullStr	Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_full_unstemmed	Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
title_sort	levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/0348aa7110814480b7ba0e9b42d62084
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Levetiracetam in management of bilateral trigeminal neuralgia due to large glomus tumor case report

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