Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells

Colorectal cancer (CRC) is ranked second for cancer-related deaths worldwide with approximately half of the patients being diagnosed at the late stages. The untimely detection of CRC results in advancement to the metastatic stage and nearly 90% of cancer-related deaths. The early detection of CRC is...

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Autores principales:	Francis Yew Fu Tieng, Nadiah Abu, Siti Nurmi Nasir, Learn-Han Lee, Nurul-Syakima Ab Mutalib
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	circulating tumor cells enrichment cell surface markers colorectal cancer blood-based screening non-invasive multiplex Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0348e3a2e5c640ea84094bbd43e5931c
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spelling	oai:doaj.org-article:0348e3a2e5c640ea84094bbd43e5931c2021-11-25T17:21:55ZLiquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells10.3390/diagnostics111121362075-4418https://doaj.org/article/0348e3a2e5c640ea84094bbd43e5931c2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2136https://doaj.org/toc/2075-4418Colorectal cancer (CRC) is ranked second for cancer-related deaths worldwide with approximately half of the patients being diagnosed at the late stages. The untimely detection of CRC results in advancement to the metastatic stage and nearly 90% of cancer-related deaths. The early detection of CRC is crucial to decrease its overall incidence and mortality rates. The recent introduction of circulating tumor cells (CTCs) has enabled a less invasive sampling method from liquid biopsies, besides revealing key information toward CRC metastasis. The current gold standard for CTC identification is the CellSearch® system (Veridex). This first-generation instrumentation relies on a single cell surface marker (CSM) to capture and count CTCs. Detection of CTCs allows the identification of patients at risk for metastasis, whereas CTC enumeration could improve risk assessment, monitoring of systemic therapy, and detection of therapy resistance in advanced metastatic CRC. In this review, we compared the pros and cons between single CSM-based CTC enrichment techniques and multi-marker-based systems. We also highlighted the challenges faced in the routine implementation of CSM-dependent CTC detection methods in CRC screening, prediction, prognosis, disease monitoring, and therapy selection toward precision medicine, as well as the dwelling on post-CTC analysis and characterization methods.Francis Yew Fu TiengNadiah AbuSiti Nurmi NasirLearn-Han LeeNurul-Syakima Ab MutalibMDPI AGarticlecirculating tumor cells enrichmentcell surface markerscolorectal cancerblood-based screeningnon-invasivemultiplexMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2136, p 2136 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circulating tumor cells enrichment cell surface markers colorectal cancer blood-based screening non-invasive multiplex Medicine (General) R5-920
spellingShingle	circulating tumor cells enrichment cell surface markers colorectal cancer blood-based screening non-invasive multiplex Medicine (General) R5-920 Francis Yew Fu Tieng Nadiah Abu Siti Nurmi Nasir Learn-Han Lee Nurul-Syakima Ab Mutalib Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells
description	Colorectal cancer (CRC) is ranked second for cancer-related deaths worldwide with approximately half of the patients being diagnosed at the late stages. The untimely detection of CRC results in advancement to the metastatic stage and nearly 90% of cancer-related deaths. The early detection of CRC is crucial to decrease its overall incidence and mortality rates. The recent introduction of circulating tumor cells (CTCs) has enabled a less invasive sampling method from liquid biopsies, besides revealing key information toward CRC metastasis. The current gold standard for CTC identification is the CellSearch® system (Veridex). This first-generation instrumentation relies on a single cell surface marker (CSM) to capture and count CTCs. Detection of CTCs allows the identification of patients at risk for metastasis, whereas CTC enumeration could improve risk assessment, monitoring of systemic therapy, and detection of therapy resistance in advanced metastatic CRC. In this review, we compared the pros and cons between single CSM-based CTC enrichment techniques and multi-marker-based systems. We also highlighted the challenges faced in the routine implementation of CSM-dependent CTC detection methods in CRC screening, prediction, prognosis, disease monitoring, and therapy selection toward precision medicine, as well as the dwelling on post-CTC analysis and characterization methods.
format	article
author	Francis Yew Fu Tieng Nadiah Abu Siti Nurmi Nasir Learn-Han Lee Nurul-Syakima Ab Mutalib
author_facet	Francis Yew Fu Tieng Nadiah Abu Siti Nurmi Nasir Learn-Han Lee Nurul-Syakima Ab Mutalib
author_sort	Francis Yew Fu Tieng
title	Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells
title_short	Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells
title_full	Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells
title_fullStr	Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells
title_full_unstemmed	Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells
title_sort	liquid biopsy-based colorectal cancer screening via surface markers of circulating tumor cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0348e3a2e5c640ea84094bbd43e5931c
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Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells

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