Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments

During the last decades, several technologies were developed for testing drug delivery through the dermal barrier. Investigation of drug penetration across the skin can be important in topical pharmaceutical formulations and also in cosmeto-science. The state-of- the-art in the field of skin diffusi...

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Autores principales:	Zsófia Varga-Medveczky, Dorottya Kocsis, Márton Bese Naszlady, Katalin Fónagy, Franciska Erdő
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	topical drug diffusion skin-on-a-chip microfluidics Franz diffusion cells skin equivalents drug delivery Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/034933ad392b4da3a7af029e4e7ab666
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spelling	oai:doaj.org-article:034933ad392b4da3a7af029e4e7ab6662021-11-25T18:41:09ZSkin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments10.3390/pharmaceutics131118521999-4923https://doaj.org/article/034933ad392b4da3a7af029e4e7ab6662021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1852https://doaj.org/toc/1999-4923During the last decades, several technologies were developed for testing drug delivery through the dermal barrier. Investigation of drug penetration across the skin can be important in topical pharmaceutical formulations and also in cosmeto-science. The state-of- the-art in the field of skin diffusion measurements, different devices, and diffusion platforms used, are summarized in the introductory part of this review. Then the methodologies applied at Pázmány Péter Catholic University are shown in detail. The main testing platforms (Franz diffusion cells, skin-on-a-chip devices) and the major scientific projects (P-glycoprotein interaction in the skin; new skin equivalents for diffusion purposes) are also presented in one section. The main achievements of our research are briefly summarized: (1) new skin-on-a-chip microfluidic devices were validated as tools for drug penetration studies for the skin; (2) P-glycoprotein transport has an absorptive orientation in the skin; (3) skin samples cannot be used for transporter interaction studies after freezing and thawing; (4) penetration of hydrophilic model drugs is lower in aged than in young skin; (5) mechanical sensitization is needed for excised rodent and pig skins for drug absorption measurements. Our validated skin-on-a-chip platform is available for other research groups to use for testing and for utilizing it for different purposes.Zsófia Varga-MedveczkyDorottya KocsisMárton Bese NaszladyKatalin FónagyFranciska ErdőMDPI AGarticletopical drug diffusionskin-on-a-chipmicrofluidicsFranz diffusion cellsskin equivalentsdrug deliveryPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1852, p 1852 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	topical drug diffusion skin-on-a-chip microfluidics Franz diffusion cells skin equivalents drug delivery Pharmacy and materia medica RS1-441
spellingShingle	topical drug diffusion skin-on-a-chip microfluidics Franz diffusion cells skin equivalents drug delivery Pharmacy and materia medica RS1-441 Zsófia Varga-Medveczky Dorottya Kocsis Márton Bese Naszlady Katalin Fónagy Franciska Erdő Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments
description	During the last decades, several technologies were developed for testing drug delivery through the dermal barrier. Investigation of drug penetration across the skin can be important in topical pharmaceutical formulations and also in cosmeto-science. The state-of- the-art in the field of skin diffusion measurements, different devices, and diffusion platforms used, are summarized in the introductory part of this review. Then the methodologies applied at Pázmány Péter Catholic University are shown in detail. The main testing platforms (Franz diffusion cells, skin-on-a-chip devices) and the major scientific projects (P-glycoprotein interaction in the skin; new skin equivalents for diffusion purposes) are also presented in one section. The main achievements of our research are briefly summarized: (1) new skin-on-a-chip microfluidic devices were validated as tools for drug penetration studies for the skin; (2) P-glycoprotein transport has an absorptive orientation in the skin; (3) skin samples cannot be used for transporter interaction studies after freezing and thawing; (4) penetration of hydrophilic model drugs is lower in aged than in young skin; (5) mechanical sensitization is needed for excised rodent and pig skins for drug absorption measurements. Our validated skin-on-a-chip platform is available for other research groups to use for testing and for utilizing it for different purposes.
format	article
author	Zsófia Varga-Medveczky Dorottya Kocsis Márton Bese Naszlady Katalin Fónagy Franciska Erdő
author_facet	Zsófia Varga-Medveczky Dorottya Kocsis Márton Bese Naszlady Katalin Fónagy Franciska Erdő
author_sort	Zsófia Varga-Medveczky
title	Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments
title_short	Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments
title_full	Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments
title_fullStr	Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments
title_full_unstemmed	Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments
title_sort	skin-on-a-chip technology for testing transdermal drug delivery—starting points and recent developments
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/034933ad392b4da3a7af029e4e7ab666
work_keys_str_mv	AT zsofiavargamedveczky skinonachiptechnologyfortestingtransdermaldrugdeliverystartingpointsandrecentdevelopments AT dorottyakocsis skinonachiptechnologyfortestingtransdermaldrugdeliverystartingpointsandrecentdevelopments AT martonbesenaszlady skinonachiptechnologyfortestingtransdermaldrugdeliverystartingpointsandrecentdevelopments AT katalinfonagy skinonachiptechnologyfortestingtransdermaldrugdeliverystartingpointsandrecentdevelopments AT franciskaerdo skinonachiptechnologyfortestingtransdermaldrugdeliverystartingpointsandrecentdevelopments
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Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery—Starting Points and Recent Developments

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