Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy

Qian Wang,1 Liping Xie,1 Zhizhu He,2 Derui Di,2 Jing Liu1,21Department of Biomedical Engineering, School of Medicine, Tsinghua University, 2Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, People&#39;s Republic of ChinaBackgrou...

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Autores principales:	Wang Q, Xie L, He Z, Di D, Liu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/034ac88ab3634039a1bfdba63aa6a259
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spelling	oai:doaj.org-article:034ac88ab3634039a1bfdba63aa6a2592021-12-02T01:04:03ZBiodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy1176-91141178-2013https://doaj.org/article/034ac88ab3634039a1bfdba63aa6a2592012-08-01T00:00:00Zhttp://www.dovepress.com/biodegradable-magnesium-nanoparticle-enhanced-laser-hyperthermia-thera-a10843https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Qian Wang,1 Liping Xie,1 Zhizhu He,2 Derui Di,2 Jing Liu1,21Department of Biomedical Engineering, School of Medicine, Tsinghua University, 2Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, People&#39;s Republic of ChinaBackground: Recently, nanoparticles have been demonstrated to have tremendous merit in terms of improving the treatment specificity and thermal ablation effect on tumors. However, the potential toxicity and long-term side effects caused by the introduced nanoparticles and by expelling them out of the body following surgery remain a significant challenge. Here, we propose for the first time to directly adopt magnesium nanoparticles as the heating enhancer in laser thermal ablation to avoid these problems by making full use of the perfect biodegradable properties of this specific material.Methods: To better understand the new nano &ldquo;green&rdquo; hyperthermia modality, we evaluated the effects of magnesium nanoparticles on the temperature transients inside the human body subject to laser interstitial heating. Further, we experimentally investigated the heating enhancement effects of magnesium nanoparticles on a group of biological samples: oil, egg white, egg yolk, in vitro pig tissues, and the in vivo hind leg of rabbit when subjected to laser irradiation.Results: Both the theoretical simulations and experimental measurements demonstrated that the target tissues injected with magnesium nanoparticles reached much higher temperatures than tissues without magnesium nanoparticles. This revealed the enhancing behavior of the new nanohyperthermia method.Conclusion: Given the unique features of magnesium nanoparticles &ndash; their complete biological safety and ability to enhance heating &ndash; which most other advanced metal nanoparticles do not possess, the use of magnesium nanoparticles in hyperthermia therapy offers an important &ldquo;green&rdquo; nanomedicine modality for treating tumors. This method has the potential to be used in clinics in the near future.Keywords: laser thermal therapy, heating enhancer, biodegradability, nanohyperthermia, bioheat transferWang QXie LHe ZDi DLiu JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4715-4725 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang Q Xie L He Z Di D Liu J Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy
description	Qian Wang,1 Liping Xie,1 Zhizhu He,2 Derui Di,2 Jing Liu1,21Department of Biomedical Engineering, School of Medicine, Tsinghua University, 2Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, People&#39;s Republic of ChinaBackground: Recently, nanoparticles have been demonstrated to have tremendous merit in terms of improving the treatment specificity and thermal ablation effect on tumors. However, the potential toxicity and long-term side effects caused by the introduced nanoparticles and by expelling them out of the body following surgery remain a significant challenge. Here, we propose for the first time to directly adopt magnesium nanoparticles as the heating enhancer in laser thermal ablation to avoid these problems by making full use of the perfect biodegradable properties of this specific material.Methods: To better understand the new nano &ldquo;green&rdquo; hyperthermia modality, we evaluated the effects of magnesium nanoparticles on the temperature transients inside the human body subject to laser interstitial heating. Further, we experimentally investigated the heating enhancement effects of magnesium nanoparticles on a group of biological samples: oil, egg white, egg yolk, in vitro pig tissues, and the in vivo hind leg of rabbit when subjected to laser irradiation.Results: Both the theoretical simulations and experimental measurements demonstrated that the target tissues injected with magnesium nanoparticles reached much higher temperatures than tissues without magnesium nanoparticles. This revealed the enhancing behavior of the new nanohyperthermia method.Conclusion: Given the unique features of magnesium nanoparticles &ndash; their complete biological safety and ability to enhance heating &ndash; which most other advanced metal nanoparticles do not possess, the use of magnesium nanoparticles in hyperthermia therapy offers an important &ldquo;green&rdquo; nanomedicine modality for treating tumors. This method has the potential to be used in clinics in the near future.Keywords: laser thermal therapy, heating enhancer, biodegradability, nanohyperthermia, bioheat transfer
format	article
author	Wang Q Xie L He Z Di D Liu J
author_facet	Wang Q Xie L He Z Di D Liu J
author_sort	Wang Q
title	Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy
title_short	Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy
title_full	Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy
title_fullStr	Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy
title_full_unstemmed	Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy
title_sort	biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/034ac88ab3634039a1bfdba63aa6a259
work_keys_str_mv	AT wangq biodegradablemagnesiumnanoparticleenhancedlaserhyperthermiatherapy AT xiel biodegradablemagnesiumnanoparticleenhancedlaserhyperthermiatherapy AT hez biodegradablemagnesiumnanoparticleenhancedlaserhyperthermiatherapy AT did biodegradablemagnesiumnanoparticleenhancedlaserhyperthermiatherapy AT liuj biodegradablemagnesiumnanoparticleenhancedlaserhyperthermiatherapy
_version_	1718403296558841856

Biodegradable magnesium nanoparticle-enhanced laser hyperthermia therapy

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