Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug

Shini Feng,1 Huijie Zhang,1 Ting Yan,1 Dandi Huang,1 Chunyi Zhi,2 Hideki Nakanishi,1 Xiao-Dong Gao1 1Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China; 2Department of Physics an...

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Autores principales:	Feng S, Zhang H, Yan T, Huang D, Zhi C, Nakanishi H, Gao XD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Boron nitride nanospheres folic acid doxorubicin targeted delivery cancer therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/034bd17d64d643ee9afaf08974a41776
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spelling	oai:doaj.org-article:034bd17d64d643ee9afaf08974a417762021-12-02T05:22:11ZFolate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug1178-2013https://doaj.org/article/034bd17d64d643ee9afaf08974a417762016-09-01T00:00:00Zhttps://www.dovepress.com/folate-conjugated-boron-nitride-nanospheres-for-targeted-delivery-of-a-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shini Feng,1 Huijie Zhang,1 Ting Yan,1 Dandi Huang,1 Chunyi Zhi,2 Hideki Nakanishi,1 Xiao-Dong Gao1 1Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China; 2Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China Abstract: With its unique physical and chemical properties and structural similarity to carbon, boron nitride (BN) has attracted considerable attention and found many applications. Biomedical applications of BN have recently started to emerge, raising great hopes in drug and gene delivery. Here, we developed a targeted anticancer drug delivery system based on folate-conjugated BN nanospheres (BNNS) with receptor-mediated targeting. Folic acid (FA) was successfully grafted onto BNNS via esterification reaction. In vitro cytotoxicity assay showed that BNNS-FA complexes were non-toxic to HeLa cells up to a concentration of 100 µg/mL. Then, doxorubicin hydrochloride (DOX), a commonly used anticancer drug, was loaded onto BNNS-FA complexes. BNNS-FA/DOX complexes were stable at pH 7.4 but effectively released DOX at pH 5.0, which exhibited a pH sensitive and sustained release pattern. BNNS-FA/DOX complexes could be recognized and specifically internalized by HeLa cells via FA receptor-mediated endocytosis. BNNS-FA/DOX complexes exhibited greater cytotoxicity to HeLa cells than free DOX and BNNS/DOX complexes due to the increased cellular uptake of DOX mediated by the FA receptor. Therefore, BNNS-FA complexes had strong potential for targeted cancer therapy. Keywords: boron nitride nanospheres, folic acid, doxorubicin, targeted delivery, cancer therapyFeng SZhang HYan THuang DZhi CNakanishi HGao XDDove Medical PressarticleBoron nitride nanospheresfolic aciddoxorubicintargeted deliverycancer therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4573-4582 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Boron nitride nanospheres folic acid doxorubicin targeted delivery cancer therapy Medicine (General) R5-920
spellingShingle	Boron nitride nanospheres folic acid doxorubicin targeted delivery cancer therapy Medicine (General) R5-920 Feng S Zhang H Yan T Huang D Zhi C Nakanishi H Gao XD Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug
description	Shini Feng,1 Huijie Zhang,1 Ting Yan,1 Dandi Huang,1 Chunyi Zhi,2 Hideki Nakanishi,1 Xiao-Dong Gao1 1Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, People’s Republic of China; 2Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China Abstract: With its unique physical and chemical properties and structural similarity to carbon, boron nitride (BN) has attracted considerable attention and found many applications. Biomedical applications of BN have recently started to emerge, raising great hopes in drug and gene delivery. Here, we developed a targeted anticancer drug delivery system based on folate-conjugated BN nanospheres (BNNS) with receptor-mediated targeting. Folic acid (FA) was successfully grafted onto BNNS via esterification reaction. In vitro cytotoxicity assay showed that BNNS-FA complexes were non-toxic to HeLa cells up to a concentration of 100 µg/mL. Then, doxorubicin hydrochloride (DOX), a commonly used anticancer drug, was loaded onto BNNS-FA complexes. BNNS-FA/DOX complexes were stable at pH 7.4 but effectively released DOX at pH 5.0, which exhibited a pH sensitive and sustained release pattern. BNNS-FA/DOX complexes could be recognized and specifically internalized by HeLa cells via FA receptor-mediated endocytosis. BNNS-FA/DOX complexes exhibited greater cytotoxicity to HeLa cells than free DOX and BNNS/DOX complexes due to the increased cellular uptake of DOX mediated by the FA receptor. Therefore, BNNS-FA complexes had strong potential for targeted cancer therapy. Keywords: boron nitride nanospheres, folic acid, doxorubicin, targeted delivery, cancer therapy
format	article
author	Feng S Zhang H Yan T Huang D Zhi C Nakanishi H Gao XD
author_facet	Feng S Zhang H Yan T Huang D Zhi C Nakanishi H Gao XD
author_sort	Feng S
title	Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug
title_short	Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug
title_full	Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug
title_fullStr	Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug
title_full_unstemmed	Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug
title_sort	folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/034bd17d64d643ee9afaf08974a41776
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Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug

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