Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

Virus-specific CD8+ T cells are crucial during H7N9 influenza infection, but CD8+ T cell dysfunction is associated with poor prognosis. Here, the authors use molecular and phenotypic analysis to establish persistence of clonally diverse CD8+ T cell populations during fatal infection.

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Autores principales:	Zhongfang Wang, Lingyan Zhu, Thi H. O. Nguyen, Yanmin Wan, Sneha Sant, Sergio M. Quiñones-Parra, Jeremy Chase Crawford, Auda A. Eltahla, Simone Rizzetto, Rowena A. Bull, Chenli Qiu, Marios Koutsakos, E. Bridie Clemens, Liyen Loh, Tianyue Chen, Lu Liu, Pengxing Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, James M. McCaw, Nicole L. La Gruta, Stephen J. Turner, Allen C. Cheng, Fabio Luciani, Xiaoyan Zhang, Peter C. Doherty, Paul G. Thomas, Jianqing Xu, Katherine Kedzierska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0354e26df1f7459caf4dc1fcf140649a
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spelling	oai:doaj.org-article:0354e26df1f7459caf4dc1fcf140649a2021-12-02T14:39:48ZClonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease10.1038/s41467-018-03243-72041-1723https://doaj.org/article/0354e26df1f7459caf4dc1fcf140649a2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03243-7https://doaj.org/toc/2041-1723Virus-specific CD8+ T cells are crucial during H7N9 influenza infection, but CD8+ T cell dysfunction is associated with poor prognosis. Here, the authors use molecular and phenotypic analysis to establish persistence of clonally diverse CD8+ T cell populations during fatal infection.Zhongfang WangLingyan ZhuThi H. O. NguyenYanmin WanSneha SantSergio M. Quiñones-ParraJeremy Chase CrawfordAuda A. EltahlaSimone RizzettoRowena A. BullChenli QiuMarios KoutsakosE. Bridie ClemensLiyen LohTianyue ChenLu LiuPengxing CaoYanqin RenLukasz KedzierskiTom KotsimbosJames M. McCawNicole L. La GrutaStephen J. TurnerAllen C. ChengFabio LucianiXiaoyan ZhangPeter C. DohertyPaul G. ThomasJianqing XuKatherine KedzierskaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongfang Wang Lingyan Zhu Thi H. O. Nguyen Yanmin Wan Sneha Sant Sergio M. Quiñones-Parra Jeremy Chase Crawford Auda A. Eltahla Simone Rizzetto Rowena A. Bull Chenli Qiu Marios Koutsakos E. Bridie Clemens Liyen Loh Tianyue Chen Lu Liu Pengxing Cao Yanqin Ren Lukasz Kedzierski Tom Kotsimbos James M. McCaw Nicole L. La Gruta Stephen J. Turner Allen C. Cheng Fabio Luciani Xiaoyan Zhang Peter C. Doherty Paul G. Thomas Jianqing Xu Katherine Kedzierska Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
description	Virus-specific CD8+ T cells are crucial during H7N9 influenza infection, but CD8+ T cell dysfunction is associated with poor prognosis. Here, the authors use molecular and phenotypic analysis to establish persistence of clonally diverse CD8+ T cell populations during fatal infection.
format	article
author	Zhongfang Wang Lingyan Zhu Thi H. O. Nguyen Yanmin Wan Sneha Sant Sergio M. Quiñones-Parra Jeremy Chase Crawford Auda A. Eltahla Simone Rizzetto Rowena A. Bull Chenli Qiu Marios Koutsakos E. Bridie Clemens Liyen Loh Tianyue Chen Lu Liu Pengxing Cao Yanqin Ren Lukasz Kedzierski Tom Kotsimbos James M. McCaw Nicole L. La Gruta Stephen J. Turner Allen C. Cheng Fabio Luciani Xiaoyan Zhang Peter C. Doherty Paul G. Thomas Jianqing Xu Katherine Kedzierska
author_facet	Zhongfang Wang Lingyan Zhu Thi H. O. Nguyen Yanmin Wan Sneha Sant Sergio M. Quiñones-Parra Jeremy Chase Crawford Auda A. Eltahla Simone Rizzetto Rowena A. Bull Chenli Qiu Marios Koutsakos E. Bridie Clemens Liyen Loh Tianyue Chen Lu Liu Pengxing Cao Yanqin Ren Lukasz Kedzierski Tom Kotsimbos James M. McCaw Nicole L. La Gruta Stephen J. Turner Allen C. Cheng Fabio Luciani Xiaoyan Zhang Peter C. Doherty Paul G. Thomas Jianqing Xu Katherine Kedzierska
author_sort	Zhongfang Wang
title	Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
title_short	Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
title_full	Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
title_fullStr	Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
title_full_unstemmed	Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
title_sort	clonally diverse cd38+hla-dr+cd8+ t cells persist during fatal h7n9 disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0354e26df1f7459caf4dc1fcf140649a
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Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

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