Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice

Age-related exacerbation of hematopoietic organ damage induced by systemic hyper-inflammation in senescence-accelerated mice

Abstract Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyper-inflammatory disorder. The mortality of HLH is higher in the elderly than in young adults. Senescence-accelerated mice (SAMP1/TA-1) exhibit characteristic accelerated aging after 30 weeks of age, and HLH-like feat...

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Autores principales: Tomonori Harada, Isao Tsuboi, Hirotsugu Hino, Miyuki Yuda, Yoko Hirabayashi, Shuichi Hirai, Shin Aizawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Medicine
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Acceso en línea:https://doaj.org/article/035b3c59f87d46d493245ef75060b768
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https://doaj.org/article/035b3c59f87d46d493245ef75060b768

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