Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system

Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were c...

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Autores principales: Kexin Zheng, Chenghao Fu, Chunying Jiang, Xiqing Yue, Shiliang Ma
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2018
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Acceso en línea:https://doaj.org/article/035f64464e2740b7a6e7fb583d6a72db
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spelling oai:doaj.org-article:035f64464e2740b7a6e7fb583d6a72db2021-11-26T11:19:46ZWater extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system0954-01051465-344310.1080/09540105.2018.1457012https://doaj.org/article/035f64464e2740b7a6e7fb583d6a72db2018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1457012https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were cultured with media supplemented with water extract of PA (WEPA), and the female BALB/c mice transplanted with 4T1 cells were treated by gavage with WEPA. The results showed that WEPA promoted the proliferation of 4T1 cells in vitro, while inhibited the growth of 4T1 tumour in vivo. In addition, WEPA increased the proportion of CD4+ T cells, CD8+ T cells and NK cells and reduced myeloid-derived suppressive cells in mouse peripheral blood. These results suggest that WEPA can inhibit the growth of mouse 4T1 tumours through modulating immune system of the mouse.Kexin ZhengChenghao FuChunying JiangXiqing YueShiliang MaTaylor & Francis Grouparticle4t1 cellsflow cytometrymdscsnk cellst cellsAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 785-796 (2018)
institution DOAJ
collection DOAJ
language EN
topic 4t1 cells
flow cytometry
mdscs
nk cells
t cells
Agriculture (General)
S1-972
Immunologic diseases. Allergy
RC581-607
spellingShingle 4t1 cells
flow cytometry
mdscs
nk cells
t cells
Agriculture (General)
S1-972
Immunologic diseases. Allergy
RC581-607
Kexin Zheng
Chenghao Fu
Chunying Jiang
Xiqing Yue
Shiliang Ma
Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
description Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were cultured with media supplemented with water extract of PA (WEPA), and the female BALB/c mice transplanted with 4T1 cells were treated by gavage with WEPA. The results showed that WEPA promoted the proliferation of 4T1 cells in vitro, while inhibited the growth of 4T1 tumour in vivo. In addition, WEPA increased the proportion of CD4+ T cells, CD8+ T cells and NK cells and reduced myeloid-derived suppressive cells in mouse peripheral blood. These results suggest that WEPA can inhibit the growth of mouse 4T1 tumours through modulating immune system of the mouse.
format article
author Kexin Zheng
Chenghao Fu
Chunying Jiang
Xiqing Yue
Shiliang Ma
author_facet Kexin Zheng
Chenghao Fu
Chunying Jiang
Xiqing Yue
Shiliang Ma
author_sort Kexin Zheng
title Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_short Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_full Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_fullStr Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_full_unstemmed Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_sort water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
publisher Taylor & Francis Group
publishDate 2018
url https://doaj.org/article/035f64464e2740b7a6e7fb583d6a72db
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AT chenghaofu waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem
AT chunyingjiang waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem
AT xiqingyue waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem
AT shiliangma waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem
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