Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system

Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kexin Zheng, Chenghao Fu, Chunying Jiang, Xiqing Yue, Shiliang Ma
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	4t1 cells flow cytometry mdscs nk cells t cells Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/035f64464e2740b7a6e7fb583d6a72db
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:035f64464e2740b7a6e7fb583d6a72db
record_format	dspace
spelling	oai:doaj.org-article:035f64464e2740b7a6e7fb583d6a72db2021-11-26T11:19:46ZWater extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system0954-01051465-344310.1080/09540105.2018.1457012https://doaj.org/article/035f64464e2740b7a6e7fb583d6a72db2018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1457012https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were cultured with media supplemented with water extract of PA (WEPA), and the female BALB/c mice transplanted with 4T1 cells were treated by gavage with WEPA. The results showed that WEPA promoted the proliferation of 4T1 cells in vitro, while inhibited the growth of 4T1 tumour in vivo. In addition, WEPA increased the proportion of CD4+ T cells, CD8+ T cells and NK cells and reduced myeloid-derived suppressive cells in mouse peripheral blood. These results suggest that WEPA can inhibit the growth of mouse 4T1 tumours through modulating immune system of the mouse.Kexin ZhengChenghao FuChunying JiangXiqing YueShiliang MaTaylor & Francis Grouparticle4t1 cellsflow cytometrymdscsnk cellst cellsAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 785-796 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	4t1 cells flow cytometry mdscs nk cells t cells Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	4t1 cells flow cytometry mdscs nk cells t cells Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Kexin Zheng Chenghao Fu Chunying Jiang Xiqing Yue Shiliang Ma Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
description	Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were cultured with media supplemented with water extract of PA (WEPA), and the female BALB/c mice transplanted with 4T1 cells were treated by gavage with WEPA. The results showed that WEPA promoted the proliferation of 4T1 cells in vitro, while inhibited the growth of 4T1 tumour in vivo. In addition, WEPA increased the proportion of CD4+ T cells, CD8+ T cells and NK cells and reduced myeloid-derived suppressive cells in mouse peripheral blood. These results suggest that WEPA can inhibit the growth of mouse 4T1 tumours through modulating immune system of the mouse.
format	article
author	Kexin Zheng Chenghao Fu Chunying Jiang Xiqing Yue Shiliang Ma
author_facet	Kexin Zheng Chenghao Fu Chunying Jiang Xiqing Yue Shiliang Ma
author_sort	Kexin Zheng
title	Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_short	Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_full	Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_fullStr	Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_full_unstemmed	Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
title_sort	water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/035f64464e2740b7a6e7fb583d6a72db
work_keys_str_mv	AT kexinzheng waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem AT chenghaofu waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem AT chunyingjiang waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem AT xiqingyue waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem AT shiliangma waterextractofpiloseantlercaninhibitbreastcancerprogressionofthemousethroughmodulatingitsimmunesystem
_version_	1718409513928753152

Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system

Ejemplares similares