Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system
Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were c...
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Taylor & Francis Group
2018
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oai:doaj.org-article:035f64464e2740b7a6e7fb583d6a72db2021-11-26T11:19:46ZWater extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system0954-01051465-344310.1080/09540105.2018.1457012https://doaj.org/article/035f64464e2740b7a6e7fb583d6a72db2018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1457012https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were cultured with media supplemented with water extract of PA (WEPA), and the female BALB/c mice transplanted with 4T1 cells were treated by gavage with WEPA. The results showed that WEPA promoted the proliferation of 4T1 cells in vitro, while inhibited the growth of 4T1 tumour in vivo. In addition, WEPA increased the proportion of CD4+ T cells, CD8+ T cells and NK cells and reduced myeloid-derived suppressive cells in mouse peripheral blood. These results suggest that WEPA can inhibit the growth of mouse 4T1 tumours through modulating immune system of the mouse.Kexin ZhengChenghao FuChunying JiangXiqing YueShiliang MaTaylor & Francis Grouparticle4t1 cellsflow cytometrymdscsnk cellst cellsAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 785-796 (2018) |
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4t1 cells flow cytometry mdscs nk cells t cells Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 |
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4t1 cells flow cytometry mdscs nk cells t cells Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Kexin Zheng Chenghao Fu Chunying Jiang Xiqing Yue Shiliang Ma Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system |
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Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing mice. The 4T1 mouse mammary tumour cells were cultured with media supplemented with water extract of PA (WEPA), and the female BALB/c mice transplanted with 4T1 cells were treated by gavage with WEPA. The results showed that WEPA promoted the proliferation of 4T1 cells in vitro, while inhibited the growth of 4T1 tumour in vivo. In addition, WEPA increased the proportion of CD4+ T cells, CD8+ T cells and NK cells and reduced myeloid-derived suppressive cells in mouse peripheral blood. These results suggest that WEPA can inhibit the growth of mouse 4T1 tumours through modulating immune system of the mouse. |
format |
article |
author |
Kexin Zheng Chenghao Fu Chunying Jiang Xiqing Yue Shiliang Ma |
author_facet |
Kexin Zheng Chenghao Fu Chunying Jiang Xiqing Yue Shiliang Ma |
author_sort |
Kexin Zheng |
title |
Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system |
title_short |
Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system |
title_full |
Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system |
title_fullStr |
Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system |
title_full_unstemmed |
Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system |
title_sort |
water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system |
publisher |
Taylor & Francis Group |
publishDate |
2018 |
url |
https://doaj.org/article/035f64464e2740b7a6e7fb583d6a72db |
work_keys_str_mv |
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