Absence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.

Methicillin-resistant Staphylococcus aureus (MRSA) has long been known as a major cause of hospital-acquired (HA-MRSA) infections worldwide. For the past twenty years, an increasing number of studies have described its emergence in the community as well. In Portugal, a country with a high-prevalence...

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Autores principales:	Sónia T Almeida, A Cristina Paulo, João Babo, João Borralho, Catarina Figueiredo, Bruno Gonçalves, João Lança, Mónica Louro, Hermes Morais, Joana Queiroz, Hermínia de Lencastre, Raquel Sá-Leão
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/035f7bd4c2f34bed9dadfe839696fb25
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spelling	oai:doaj.org-article:035f7bd4c2f34bed9dadfe839696fb252021-12-02T20:15:44ZAbsence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.1932-620310.1371/journal.pone.0253739https://doaj.org/article/035f7bd4c2f34bed9dadfe839696fb252021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253739https://doaj.org/toc/1932-6203Methicillin-resistant Staphylococcus aureus (MRSA) has long been known as a major cause of hospital-acquired (HA-MRSA) infections worldwide. For the past twenty years, an increasing number of studies have described its emergence in the community as well. In Portugal, a country with a high-prevalence of HA-MRSA, there are only limited data available on the epidemiology of MRSA in the community. We studied the prevalence of S. aureus and MRSA colonization among healthy adults in Portugal. Between February 2015 and December 2016, a longitudinal study was conducted in which 87 adults aged 25-50 years old were followed for six months. For each participant nasopharyngeal, oropharyngeal and saliva samples were obtained monthly and, in some cases, weekly. A total of 1,578 samples (n = 526 for each sampling site) were examined for the presence of S. aureus and MRSA by classical culture-based methods. Fifty-seven adults (65.5%) carried S. aureus at least once during the six months period of the study: 19.5% were persistent S. aureus carriers and 46.0% were intermittent carriers. Carriage rates per sampling site were 20.5% in nasopharynx, 18.3% in oropharynx, and 13.5% in saliva. Simultaneous screening of the three sampling sites increased detection of S. aureus, which overall occurred in 34.4% of the 526 sampling time-points. No MRSA were isolated. In conclusion, this study adds novel information about the MRSA scenario in the Portuguese community. Our results indicate that, in Portugal, MRSA does not seem to circulate among healthy adults without risk factors and therefore this age group does not constitute, at the current time, a reservoir of MRSA in the community.Sónia T AlmeidaA Cristina PauloJoão BaboJoão BorralhoCatarina FigueiredoBruno GonçalvesJoão LançaMónica LouroHermes MoraisJoana QueirozHermínia de LencastreRaquel Sá-LeãoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253739 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sónia T Almeida A Cristina Paulo João Babo João Borralho Catarina Figueiredo Bruno Gonçalves João Lança Mónica Louro Hermes Morais Joana Queiroz Hermínia de Lencastre Raquel Sá-Leão Absence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.
description	Methicillin-resistant Staphylococcus aureus (MRSA) has long been known as a major cause of hospital-acquired (HA-MRSA) infections worldwide. For the past twenty years, an increasing number of studies have described its emergence in the community as well. In Portugal, a country with a high-prevalence of HA-MRSA, there are only limited data available on the epidemiology of MRSA in the community. We studied the prevalence of S. aureus and MRSA colonization among healthy adults in Portugal. Between February 2015 and December 2016, a longitudinal study was conducted in which 87 adults aged 25-50 years old were followed for six months. For each participant nasopharyngeal, oropharyngeal and saliva samples were obtained monthly and, in some cases, weekly. A total of 1,578 samples (n = 526 for each sampling site) were examined for the presence of S. aureus and MRSA by classical culture-based methods. Fifty-seven adults (65.5%) carried S. aureus at least once during the six months period of the study: 19.5% were persistent S. aureus carriers and 46.0% were intermittent carriers. Carriage rates per sampling site were 20.5% in nasopharynx, 18.3% in oropharynx, and 13.5% in saliva. Simultaneous screening of the three sampling sites increased detection of S. aureus, which overall occurred in 34.4% of the 526 sampling time-points. No MRSA were isolated. In conclusion, this study adds novel information about the MRSA scenario in the Portuguese community. Our results indicate that, in Portugal, MRSA does not seem to circulate among healthy adults without risk factors and therefore this age group does not constitute, at the current time, a reservoir of MRSA in the community.
format	article
author	Sónia T Almeida A Cristina Paulo João Babo João Borralho Catarina Figueiredo Bruno Gonçalves João Lança Mónica Louro Hermes Morais Joana Queiroz Hermínia de Lencastre Raquel Sá-Leão
author_facet	Sónia T Almeida A Cristina Paulo João Babo João Borralho Catarina Figueiredo Bruno Gonçalves João Lança Mónica Louro Hermes Morais Joana Queiroz Hermínia de Lencastre Raquel Sá-Leão
author_sort	Sónia T Almeida
title	Absence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.
title_short	Absence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.
title_full	Absence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.
title_fullStr	Absence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.
title_full_unstemmed	Absence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.
title_sort	absence of methicillin-resistant staphylococcus aureus colonization among immunocompetent healthy adults: insights from a longitudinal study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/035f7bd4c2f34bed9dadfe839696fb25
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Absence of methicillin-resistant Staphylococcus aureus colonization among immunocompetent healthy adults: Insights from a longitudinal study.

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