Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases

It is known that estrogens can affect the immune response to cancer. Here, the authors show that estrogen depletion through ovariectomy reduces the extent of liver metastasis and that this is accompanied by a decrease in the number and function of immunosuppressive cells in the metastatic microenvir...

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Autores principales:	Simon Milette, Masakazu Hashimoto, Stephanie Perrino, Shu Qi, Michely Chen, Boram Ham, Ni Wang, Roman Istomine, Andrew M. Lowy, Ciriaco A. Piccirillo, Pnina Brodt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03601799ff694067bb6f3ab7d58e813f
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spelling	oai:doaj.org-article:03601799ff694067bb6f3ab7d58e813f2021-12-02T15:36:20ZSexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases10.1038/s41467-019-13571-x2041-1723https://doaj.org/article/03601799ff694067bb6f3ab7d58e813f2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13571-xhttps://doaj.org/toc/2041-1723It is known that estrogens can affect the immune response to cancer. Here, the authors show that estrogen depletion through ovariectomy reduces the extent of liver metastasis and that this is accompanied by a decrease in the number and function of immunosuppressive cells in the metastatic microenvironment.Simon MiletteMasakazu HashimotoStephanie PerrinoShu QiMichely ChenBoram HamNi WangRoman IstomineAndrew M. LowyCiriaco A. PiccirilloPnina BrodtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Milette Masakazu Hashimoto Stephanie Perrino Shu Qi Michely Chen Boram Ham Ni Wang Roman Istomine Andrew M. Lowy Ciriaco A. Piccirillo Pnina Brodt Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
description	It is known that estrogens can affect the immune response to cancer. Here, the authors show that estrogen depletion through ovariectomy reduces the extent of liver metastasis and that this is accompanied by a decrease in the number and function of immunosuppressive cells in the metastatic microenvironment.
format	article
author	Simon Milette Masakazu Hashimoto Stephanie Perrino Shu Qi Michely Chen Boram Ham Ni Wang Roman Istomine Andrew M. Lowy Ciriaco A. Piccirillo Pnina Brodt
author_facet	Simon Milette Masakazu Hashimoto Stephanie Perrino Shu Qi Michely Chen Boram Ham Ni Wang Roman Istomine Andrew M. Lowy Ciriaco A. Piccirillo Pnina Brodt
author_sort	Simon Milette
title	Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
title_short	Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
title_full	Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
title_fullStr	Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
title_full_unstemmed	Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
title_sort	sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/03601799ff694067bb6f3ab7d58e813f
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Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases

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