Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

The in vivo identification of proteins secreted from a specific cell type or tissue remains challenging. Here, the authors develop a proximity labeling-based method to selectively label secreted proteins and combine it with proteomics to identify liver secretory proteins in mouse plasma.

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Autores principales:	Kwang-eun Kim, Isaac Park, Jeesoo Kim, Myeong-Gyun Kang, Won Gun Choi, Hyemi Shin, Jong-Seo Kim, Hyun-Woo Rhee, Jae Myoung Suh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/036032b07306474e82815d315a525a91
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spelling	oai:doaj.org-article:036032b07306474e82815d315a525a912021-12-02T15:25:36ZDynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice10.1038/s41467-021-25546-y2041-1723https://doaj.org/article/036032b07306474e82815d315a525a912021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25546-yhttps://doaj.org/toc/2041-1723The in vivo identification of proteins secreted from a specific cell type or tissue remains challenging. Here, the authors develop a proximity labeling-based method to selectively label secreted proteins and combine it with proteomics to identify liver secretory proteins in mouse plasma.Kwang-eun KimIsaac ParkJeesoo KimMyeong-Gyun KangWon Gun ChoiHyemi ShinJong-Seo KimHyun-Woo RheeJae Myoung SuhNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kwang-eun Kim Isaac Park Jeesoo Kim Myeong-Gyun Kang Won Gun Choi Hyemi Shin Jong-Seo Kim Hyun-Woo Rhee Jae Myoung Suh Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
description	The in vivo identification of proteins secreted from a specific cell type or tissue remains challenging. Here, the authors develop a proximity labeling-based method to selectively label secreted proteins and combine it with proteomics to identify liver secretory proteins in mouse plasma.
format	article
author	Kwang-eun Kim Isaac Park Jeesoo Kim Myeong-Gyun Kang Won Gun Choi Hyemi Shin Jong-Seo Kim Hyun-Woo Rhee Jae Myoung Suh
author_facet	Kwang-eun Kim Isaac Park Jeesoo Kim Myeong-Gyun Kang Won Gun Choi Hyemi Shin Jong-Seo Kim Hyun-Woo Rhee Jae Myoung Suh
author_sort	Kwang-eun Kim
title	Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
title_short	Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
title_full	Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
title_fullStr	Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
title_full_unstemmed	Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
title_sort	dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/036032b07306474e82815d315a525a91
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Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

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