H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress

H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress

Transcription-replication conflicts (TRC) can contribute to genome instability. Here the authors reveal that under replication stress H3K4 methylation can play a role in TRC prevention.

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Autores principales: Shin Yen Chong, Sam Cutler, Jing-Jer Lin, Cheng-Hung Tsai, Huai-Kuang Tsai, Sue Biggins, Toshio Tsukiyama, Yi-Chen Lo, Cheng-Fu Kao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/03614e9236ea440180cb45b738186f2e
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spelling oai:doaj.org-article:03614e9236ea440180cb45b738186f2e2021-12-02T15:39:10ZH3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress10.1038/s41467-020-14595-42041-1723https://doaj.org/article/03614e9236ea440180cb45b738186f2e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14595-4https://doaj.org/toc/2041-1723Transcription-replication conflicts (TRC) can contribute to genome instability. Here the authors reveal that under replication stress H3K4 methylation can play a role in TRC prevention.Shin Yen ChongSam CutlerJing-Jer LinCheng-Hung TsaiHuai-Kuang TsaiSue BigginsToshio TsukiyamaYi-Chen LoCheng-Fu KaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shin Yen Chong
Sam Cutler
Jing-Jer Lin
Cheng-Hung Tsai
Huai-Kuang Tsai
Sue Biggins
Toshio Tsukiyama
Yi-Chen Lo
Cheng-Fu Kao
H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
description Transcription-replication conflicts (TRC) can contribute to genome instability. Here the authors reveal that under replication stress H3K4 methylation can play a role in TRC prevention.
format article
author Shin Yen Chong
Sam Cutler
Jing-Jer Lin
Cheng-Hung Tsai
Huai-Kuang Tsai
Sue Biggins
Toshio Tsukiyama
Yi-Chen Lo
Cheng-Fu Kao
author_facet Shin Yen Chong
Sam Cutler
Jing-Jer Lin
Cheng-Hung Tsai
Huai-Kuang Tsai
Sue Biggins
Toshio Tsukiyama
Yi-Chen Lo
Cheng-Fu Kao
author_sort Shin Yen Chong
title H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
title_short H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
title_full H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
title_fullStr H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
title_full_unstemmed H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
title_sort h3k4 methylation at active genes mitigates transcription-replication conflicts during replication stress
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/03614e9236ea440180cb45b738186f2e
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