Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

Interleukin-6 (IL-6) is increased in obesity and activates T cells to promote inflammation. Here, Xuet al. use mice that lack IL-6 receptors on T cells to uncover the temporal and tissue-specific effects of classic and trans IL-6 signalling on inflammation and insulin resistance on a high-fat diet.

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Autores principales:	Elaine Xu, Mafalda M. A. Pereira, Ismene Karakasilioti, Sebastian Theurich, Mona Al-Maarri, Gunter Rappl, Ari Waisman, F. Thomas Wunderlich, Jens C. Brüning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03626f789b1e44eea8f9d27820e6c468
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spelling	oai:doaj.org-article:03626f789b1e44eea8f9d27820e6c4682021-12-02T17:01:22ZTemporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance10.1038/ncomms148032041-1723https://doaj.org/article/03626f789b1e44eea8f9d27820e6c4682017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms14803https://doaj.org/toc/2041-1723Interleukin-6 (IL-6) is increased in obesity and activates T cells to promote inflammation. Here, Xuet al. use mice that lack IL-6 receptors on T cells to uncover the temporal and tissue-specific effects of classic and trans IL-6 signalling on inflammation and insulin resistance on a high-fat diet.Elaine XuMafalda M. A. PereiraIsmene KarakasiliotiSebastian TheurichMona Al-MaarriGunter RapplAri WaismanF. Thomas WunderlichJens C. BrüningNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elaine Xu Mafalda M. A. Pereira Ismene Karakasilioti Sebastian Theurich Mona Al-Maarri Gunter Rappl Ari Waisman F. Thomas Wunderlich Jens C. Brüning Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
description	Interleukin-6 (IL-6) is increased in obesity and activates T cells to promote inflammation. Here, Xuet al. use mice that lack IL-6 receptors on T cells to uncover the temporal and tissue-specific effects of classic and trans IL-6 signalling on inflammation and insulin resistance on a high-fat diet.
format	article
author	Elaine Xu Mafalda M. A. Pereira Ismene Karakasilioti Sebastian Theurich Mona Al-Maarri Gunter Rappl Ari Waisman F. Thomas Wunderlich Jens C. Brüning
author_facet	Elaine Xu Mafalda M. A. Pereira Ismene Karakasilioti Sebastian Theurich Mona Al-Maarri Gunter Rappl Ari Waisman F. Thomas Wunderlich Jens C. Brüning
author_sort	Elaine Xu
title	Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
title_short	Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
title_full	Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
title_fullStr	Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
title_full_unstemmed	Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
title_sort	temporal and tissue-specific requirements for t-lymphocyte il-6 signalling in obesity-associated inflammation and insulin resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/03626f789b1e44eea8f9d27820e6c468
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Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

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