Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

Interleukin-6 (IL-6) is increased in obesity and activates T cells to promote inflammation. Here, Xuet al. use mice that lack IL-6 receptors on T cells to uncover the temporal and tissue-specific effects of classic and trans IL-6 signalling on inflammation and insulin resistance on a high-fat diet.

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Detalles Bibliográficos
Autores principales: Elaine Xu, Mafalda M. A. Pereira, Ismene Karakasilioti, Sebastian Theurich, Mona Al-Maarri, Gunter Rappl, Ari Waisman, F. Thomas Wunderlich, Jens C. Brüning
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/03626f789b1e44eea8f9d27820e6c468
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