Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

Aging skeletal muscle shows declining numbers and activity of satellite cells. Here, Franco et al. show that in satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched in exons and promoters of genes involved in muscle...

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Autores principales:	Irene Franco, Anna Johansson, Karl Olsson, Peter Vrtačnik, Pär Lundin, Hafdis T. Helgadottir, Malin Larsson, Gwladys Revêchon, Carla Bosia, Andrea Pagnani, Paolo Provero, Thomas Gustafsson, Helene Fischer, Maria Eriksson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0363043147a94b90adfd4993239327c0
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spelling	oai:doaj.org-article:0363043147a94b90adfd4993239327c02021-12-02T14:41:16ZSomatic mutagenesis in satellite cells associates with human skeletal muscle aging10.1038/s41467-018-03244-62041-1723https://doaj.org/article/0363043147a94b90adfd4993239327c02018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03244-6https://doaj.org/toc/2041-1723Aging skeletal muscle shows declining numbers and activity of satellite cells. Here, Franco et al. show that in satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched in exons and promoters of genes involved in muscle function.Irene FrancoAnna JohanssonKarl OlssonPeter VrtačnikPär LundinHafdis T. HelgadottirMalin LarssonGwladys RevêchonCarla BosiaAndrea PagnaniPaolo ProveroThomas GustafssonHelene FischerMaria ErikssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irene Franco Anna Johansson Karl Olsson Peter Vrtačnik Pär Lundin Hafdis T. Helgadottir Malin Larsson Gwladys Revêchon Carla Bosia Andrea Pagnani Paolo Provero Thomas Gustafsson Helene Fischer Maria Eriksson Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
description	Aging skeletal muscle shows declining numbers and activity of satellite cells. Here, Franco et al. show that in satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched in exons and promoters of genes involved in muscle function.
format	article
author	Irene Franco Anna Johansson Karl Olsson Peter Vrtačnik Pär Lundin Hafdis T. Helgadottir Malin Larsson Gwladys Revêchon Carla Bosia Andrea Pagnani Paolo Provero Thomas Gustafsson Helene Fischer Maria Eriksson
author_facet	Irene Franco Anna Johansson Karl Olsson Peter Vrtačnik Pär Lundin Hafdis T. Helgadottir Malin Larsson Gwladys Revêchon Carla Bosia Andrea Pagnani Paolo Provero Thomas Gustafsson Helene Fischer Maria Eriksson
author_sort	Irene Franco
title	Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
title_short	Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
title_full	Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
title_fullStr	Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
title_full_unstemmed	Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
title_sort	somatic mutagenesis in satellite cells associates with human skeletal muscle aging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0363043147a94b90adfd4993239327c0
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_version_	1718389911464181760

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

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