Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems

Responsive hydrogels are of interest for diagnostic and controlled drug release applications. Here, the authors report on the design of a hydrogel with protein triggered release of an embedded protein through recovery of enzyme activity and subsequent degradation of supramolecular fibers.

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Autores principales:	Hajime Shigemitsu, Ryou Kubota, Keisuke Nakamura, Tomonobu Matsuzaki, Saori Minami, Takuma Aoyama, Kenji Urayama, Itaru Hamachi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/036386edb2de4ec6a7aab2140763fdac
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spelling	oai:doaj.org-article:036386edb2de4ec6a7aab2140763fdac2021-12-02T16:13:38ZProtein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems10.1038/s41467-020-17698-02041-1723https://doaj.org/article/036386edb2de4ec6a7aab2140763fdac2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17698-0https://doaj.org/toc/2041-1723Responsive hydrogels are of interest for diagnostic and controlled drug release applications. Here, the authors report on the design of a hydrogel with protein triggered release of an embedded protein through recovery of enzyme activity and subsequent degradation of supramolecular fibers.Hajime ShigemitsuRyou KubotaKeisuke NakamuraTomonobu MatsuzakiSaori MinamiTakuma AoyamaKenji UrayamaItaru HamachiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hajime Shigemitsu Ryou Kubota Keisuke Nakamura Tomonobu Matsuzaki Saori Minami Takuma Aoyama Kenji Urayama Itaru Hamachi Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
description	Responsive hydrogels are of interest for diagnostic and controlled drug release applications. Here, the authors report on the design of a hydrogel with protein triggered release of an embedded protein through recovery of enzyme activity and subsequent degradation of supramolecular fibers.
format	article
author	Hajime Shigemitsu Ryou Kubota Keisuke Nakamura Tomonobu Matsuzaki Saori Minami Takuma Aoyama Kenji Urayama Itaru Hamachi
author_facet	Hajime Shigemitsu Ryou Kubota Keisuke Nakamura Tomonobu Matsuzaki Saori Minami Takuma Aoyama Kenji Urayama Itaru Hamachi
author_sort	Hajime Shigemitsu
title	Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
title_short	Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
title_full	Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
title_fullStr	Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
title_full_unstemmed	Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
title_sort	protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/036386edb2de4ec6a7aab2140763fdac
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Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems

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