Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.

<h4>Background</h4>S-phase kinase protein 2 (Skp2), an oncogenic protein, is a key regulator in different cellular and molecular processes, through ubiquitin-proteasome degradation pathway. Increased levels of Skp2 are observed in various types of cancer and associated with poor prognosi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jing Liu, Xiao-Long Wei, Wen-He Huang, Chun-Fa Chen, Jing-Wen Bai, Guo-Jun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0364db54e09a4be38bb799f7024ea95b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0364db54e09a4be38bb799f7024ea95b
record_format	dspace
spelling	oai:doaj.org-article:0364db54e09a4be38bb799f7024ea95b2021-11-18T08:03:28ZCytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.1932-620310.1371/journal.pone.0052675https://doaj.org/article/0364db54e09a4be38bb799f7024ea95b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300741/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>S-phase kinase protein 2 (Skp2), an oncogenic protein, is a key regulator in different cellular and molecular processes, through ubiquitin-proteasome degradation pathway. Increased levels of Skp2 are observed in various types of cancer and associated with poor prognosis. However, in human breast carcinomas, the underlying mechanism and prognostic significance of cytoplasmic Skp2 is still undefined.<h4>Methods</h4>To investigate the role of cytoplasmic Skp2 expression in human breast carcinomas, we immnohistochemically assessed cytoplasmic Skp2, p-Akt1, and p27 expression in 251 patients with invasive ductal carcinomas of the breast. Association of cytoplasmic Skp2 expression with p-Akt1 and p27 was analyzed as well as correspondence with other clinicopathological parameters. Disease-free survival and overall survival were determined based on the Kaplan-Meier method and Cox regression models.<h4>Results</h4>Cytoplasmic of Skp2 was detected in 165 out of 251 (65.7%) patients. Cytoplasmic Skp2 expression was associated with larger tumor size, more advanced histological grade, and positive HER2 expression. Increased cytoplasmic Skp2 expression correlated with p-Akt1 expression, with 54.2% (51/94) of low p-Akt1-expressing breast carcinomas, but 72.6% (114/157) of high p-Akt1-expressing breast carcinomas exhibiting cytoplasmic Skp2 expression. Elevated cytoplasmic Skp2 expression with low p-Akt1 expression was associated with poor disease-free and overall survival (DFS and OS), and Cox regression models demonstrated that cytoplasmic Skp2 expression was an independent prognostic marker for invasive breast carcinomas.<h4>Conclusion</h4>Cytoplasmic Skp2 expression is associated with aggressive prognostic factors, such as larger tumor size, and advanced histological grade of the breast cancers. Results demonstrate that combined cytoplasmic Skp2 and p-Akt1 expression may be prognostic for patients with invasive breast carcinomas, and cytoplasmic Skp2 may serve as a potential therapeutic target.Jing LiuXiao-Long WeiWen-He HuangChun-Fa ChenJing-Wen BaiGuo-Jun ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52675 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Liu Xiao-Long Wei Wen-He Huang Chun-Fa Chen Jing-Wen Bai Guo-Jun Zhang Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.
description	<h4>Background</h4>S-phase kinase protein 2 (Skp2), an oncogenic protein, is a key regulator in different cellular and molecular processes, through ubiquitin-proteasome degradation pathway. Increased levels of Skp2 are observed in various types of cancer and associated with poor prognosis. However, in human breast carcinomas, the underlying mechanism and prognostic significance of cytoplasmic Skp2 is still undefined.<h4>Methods</h4>To investigate the role of cytoplasmic Skp2 expression in human breast carcinomas, we immnohistochemically assessed cytoplasmic Skp2, p-Akt1, and p27 expression in 251 patients with invasive ductal carcinomas of the breast. Association of cytoplasmic Skp2 expression with p-Akt1 and p27 was analyzed as well as correspondence with other clinicopathological parameters. Disease-free survival and overall survival were determined based on the Kaplan-Meier method and Cox regression models.<h4>Results</h4>Cytoplasmic of Skp2 was detected in 165 out of 251 (65.7%) patients. Cytoplasmic Skp2 expression was associated with larger tumor size, more advanced histological grade, and positive HER2 expression. Increased cytoplasmic Skp2 expression correlated with p-Akt1 expression, with 54.2% (51/94) of low p-Akt1-expressing breast carcinomas, but 72.6% (114/157) of high p-Akt1-expressing breast carcinomas exhibiting cytoplasmic Skp2 expression. Elevated cytoplasmic Skp2 expression with low p-Akt1 expression was associated with poor disease-free and overall survival (DFS and OS), and Cox regression models demonstrated that cytoplasmic Skp2 expression was an independent prognostic marker for invasive breast carcinomas.<h4>Conclusion</h4>Cytoplasmic Skp2 expression is associated with aggressive prognostic factors, such as larger tumor size, and advanced histological grade of the breast cancers. Results demonstrate that combined cytoplasmic Skp2 and p-Akt1 expression may be prognostic for patients with invasive breast carcinomas, and cytoplasmic Skp2 may serve as a potential therapeutic target.
format	article
author	Jing Liu Xiao-Long Wei Wen-He Huang Chun-Fa Chen Jing-Wen Bai Guo-Jun Zhang
author_facet	Jing Liu Xiao-Long Wei Wen-He Huang Chun-Fa Chen Jing-Wen Bai Guo-Jun Zhang
author_sort	Jing Liu
title	Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.
title_short	Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.
title_full	Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.
title_fullStr	Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.
title_full_unstemmed	Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.
title_sort	cytoplasmic skp2 expression is associated with p-akt1 and predicts poor prognosis in human breast carcinomas.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0364db54e09a4be38bb799f7024ea95b
work_keys_str_mv	AT jingliu cytoplasmicskp2expressionisassociatedwithpakt1andpredictspoorprognosisinhumanbreastcarcinomas AT xiaolongwei cytoplasmicskp2expressionisassociatedwithpakt1andpredictspoorprognosisinhumanbreastcarcinomas AT wenhehuang cytoplasmicskp2expressionisassociatedwithpakt1andpredictspoorprognosisinhumanbreastcarcinomas AT chunfachen cytoplasmicskp2expressionisassociatedwithpakt1andpredictspoorprognosisinhumanbreastcarcinomas AT jingwenbai cytoplasmicskp2expressionisassociatedwithpakt1andpredictspoorprognosisinhumanbreastcarcinomas AT guojunzhang cytoplasmicskp2expressionisassociatedwithpakt1andpredictspoorprognosisinhumanbreastcarcinomas
_version_	1718422583772184576

Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas.

Ejemplares similares