Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study

Objectives: To investigate if preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), or mean platelet volume (MPV) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (AAA) repair. Methods: We retrospectively reviewed 382 pa...

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Autores principales:	Da Eun Ko, Hei Jin Yoon, Sang Beom Nam, Suk Won Song, Gisong Lee, Sung Yeon Ham
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neutrophil to lymphocyte ratio platelet to lymphocyte ratio mean platelet volume aortic surgery abdominal aortic aneurysm Medicine R
Acceso en línea:	https://doaj.org/article/0368394c9de440a696170f5fb354abc8
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spelling	oai:doaj.org-article:0368394c9de440a696170f5fb354abc82021-11-25T18:02:32ZPreoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study10.3390/jcm102254102077-0383https://doaj.org/article/0368394c9de440a696170f5fb354abc82021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5410https://doaj.org/toc/2077-0383Objectives: To investigate if preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), or mean platelet volume (MPV) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (AAA) repair. Methods: We retrospectively reviewed 382 patients who underwent open AAA repair between January 2008 and July 2019. We divided the patients into two groups based on 1-year mortality and compared the preoperative NLR, PLR, and MPV. The patients were then classified into tertiles based on their preoperative NLR (first tertile: <2.41 (<i>n</i> = 111); second tertile: 2.41 ≤ NLR ≤ 6.07 (<i>n</i> = 111); and third tertile: >6.07 (<i>n</i> = 112)). We compared the incidence of mortality and morbidity across the aforementioned tertiles. We performed a stepwise logistic regression analysis to evaluate the predictors for mortality. An additional subgroup analysis was performed by dividing the cases into non-ruptured and ruptured cases. Results: The preoperative NLR was significantly higher in the non-survivor group than in the survivor group (10.53 ± 7.60 vs. 5.76 ± 6.44, respectively, <i>p</i> = 0.003). The PLR and MPV were similar between the groups (145.35 ± 91.11 vs. 154.20 ± 113.19, <i>p</i> = 0.626, 9.38 ± 1.20 vs. 9.11 ± 1.39, <i>p</i> = 0.267, respectively). The incidence of 1-year mortality was 2.7%, 9.0%, and 14.3% in the first, second, and third NLR tertiles, respectively (<i>p</i> = 0.009). Higher NLR (odds ratio 1.085, 95% confidence interval 1.016–1.159, <i>p</i> = 0.015) and ruptured AAA (odds ratio 2.706, 95% confidence interval 1.097–6.673, <i>p</i> = 0.031) were the independent predictors of 1-year mortality in all patients. Moreover, the preoperative NLR was significantly higher in the ruptured AAA than in the non-ruptured AAA group (11.17 ± 7.90 vs. 4.10 ± 4.75, <i>p</i> < 0.001). In subgroup analysis, preoperative NLR (odds ratio 1.144, 95% confidence interval 1.031–1.271, <i>p</i> = 0.012) and PLR (odds ratio 0.986, 95% confidence interval 16 0.975–0.998, <i>p</i> = 0.017) was an independent predictor for 1-year mortality in ruptured cases. Conclusions: We demonstrated an independent relationship between the preoperative NLR and 1-year mortality in patients undergoing open AAA repair, besides PLR and MPV. Furthermore, the NLR and PLR had predictive power for 1-year mortality in ruptured cases.Da Eun KoHei Jin YoonSang Beom NamSuk Won SongGisong LeeSung Yeon HamMDPI AGarticleneutrophil to lymphocyte ratioplatelet to lymphocyte ratiomean platelet volumeaortic surgeryabdominal aortic aneurysmMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5410, p 5410 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophil to lymphocyte ratio platelet to lymphocyte ratio mean platelet volume aortic surgery abdominal aortic aneurysm Medicine R
spellingShingle	neutrophil to lymphocyte ratio platelet to lymphocyte ratio mean platelet volume aortic surgery abdominal aortic aneurysm Medicine R Da Eun Ko Hei Jin Yoon Sang Beom Nam Suk Won Song Gisong Lee Sung Yeon Ham Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study
description	Objectives: To investigate if preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), or mean platelet volume (MPV) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (AAA) repair. Methods: We retrospectively reviewed 382 patients who underwent open AAA repair between January 2008 and July 2019. We divided the patients into two groups based on 1-year mortality and compared the preoperative NLR, PLR, and MPV. The patients were then classified into tertiles based on their preoperative NLR (first tertile: <2.41 (<i>n</i> = 111); second tertile: 2.41 ≤ NLR ≤ 6.07 (<i>n</i> = 111); and third tertile: >6.07 (<i>n</i> = 112)). We compared the incidence of mortality and morbidity across the aforementioned tertiles. We performed a stepwise logistic regression analysis to evaluate the predictors for mortality. An additional subgroup analysis was performed by dividing the cases into non-ruptured and ruptured cases. Results: The preoperative NLR was significantly higher in the non-survivor group than in the survivor group (10.53 ± 7.60 vs. 5.76 ± 6.44, respectively, <i>p</i> = 0.003). The PLR and MPV were similar between the groups (145.35 ± 91.11 vs. 154.20 ± 113.19, <i>p</i> = 0.626, 9.38 ± 1.20 vs. 9.11 ± 1.39, <i>p</i> = 0.267, respectively). The incidence of 1-year mortality was 2.7%, 9.0%, and 14.3% in the first, second, and third NLR tertiles, respectively (<i>p</i> = 0.009). Higher NLR (odds ratio 1.085, 95% confidence interval 1.016–1.159, <i>p</i> = 0.015) and ruptured AAA (odds ratio 2.706, 95% confidence interval 1.097–6.673, <i>p</i> = 0.031) were the independent predictors of 1-year mortality in all patients. Moreover, the preoperative NLR was significantly higher in the ruptured AAA than in the non-ruptured AAA group (11.17 ± 7.90 vs. 4.10 ± 4.75, <i>p</i> < 0.001). In subgroup analysis, preoperative NLR (odds ratio 1.144, 95% confidence interval 1.031–1.271, <i>p</i> = 0.012) and PLR (odds ratio 0.986, 95% confidence interval 16 0.975–0.998, <i>p</i> = 0.017) was an independent predictor for 1-year mortality in ruptured cases. Conclusions: We demonstrated an independent relationship between the preoperative NLR and 1-year mortality in patients undergoing open AAA repair, besides PLR and MPV. Furthermore, the NLR and PLR had predictive power for 1-year mortality in ruptured cases.
format	article
author	Da Eun Ko Hei Jin Yoon Sang Beom Nam Suk Won Song Gisong Lee Sung Yeon Ham
author_facet	Da Eun Ko Hei Jin Yoon Sang Beom Nam Suk Won Song Gisong Lee Sung Yeon Ham
author_sort	Da Eun Ko
title	Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study
title_short	Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study
title_full	Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study
title_fullStr	Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study
title_full_unstemmed	Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study
title_sort	preoperative neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and mean platelet volume as predictors of 1-year mortality in patients undergoing an open repair of abdominal aortic aneurysms: a retrospective study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0368394c9de440a696170f5fb354abc8
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Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study

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