4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity

4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity

Abstract Amyloid deposits in pancreatic islets, mainly formed by human islet amyloid polypeptide (hIAPP) aggregation, have been associated with loss of β-cell mass and function, and are a pathological hallmark of type 2 diabetes (T2D). Treatment with chaperones has been associated with a decrease in...

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Autores principales: Sara de Pablo, Júlia Rodríguez-Comas, Daniela Díaz-Catalán, Gema Alcarraz-Vizán, Carlos Castaño, Juan Moreno-Vedia, Joel Montane, Marcelina Parrizas, Joan-Marc Servitja, Anna Novials
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/0369fa00d1f7444587242a36dc3bc794
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