Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs
Chunling Wang,1 Xiaobo Cheng,2 Yuqing Su,1 Ying Pei,3 Yanzhi Song,1 Jiao Jiao,1 Zhenjun Huang,1 Yanfei Ma,1 Yinming Dong,1 Ying Yao,1 Jingjing Fan,1 Han Ta,1 Xinrong Liu,1 Hui Xu,1 Yihui Deng1 1College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2015
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/036b5345a923493fb6054721b48bfa55 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:036b5345a923493fb6054721b48bfa55 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:036b5345a923493fb6054721b48bfa552021-12-02T02:51:11ZAccelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs1178-2013https://doaj.org/article/036b5345a923493fb6054721b48bfa552015-05-01T00:00:00Zhttp://www.dovepress.com/accelerated-blood-clearance-phenomenon-upon-cross-administration-of-pe-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chunling Wang,1 Xiaobo Cheng,2 Yuqing Su,1 Ying Pei,3 Yanzhi Song,1 Jiao Jiao,1 Zhenjun Huang,1 Yanfei Ma,1 Yinming Dong,1 Ying Yao,1 Jingjing Fan,1 Han Ta,1 Xinrong Liu,1 Hui Xu,1 Yihui Deng1 1College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; 2Deli Wei Biological Technology Co, Ltd, Beijing, People’s Republic of China; 3Shenyang Women’s and Children’s Hospital, Shenyang, People’s Republic of China Abstract: The cross-administration of nanocarriers modified by poly(ethylene glycol) (PEG), named PEGylated nanocarriers, a type of combination therapy, is becoming an increasingly important method of long-term drug delivery, to decrease side effects, avoid multidrug resistance, and increase therapeutic efficacy. However, repeated injections of PEGylated nanocarriers induces the accelerated blood clearance (ABC) phenomenon, prevents long circulation, and can cause adverse effects owing to alterations in the biodistribution of the drug. Although the nature of the ABC phenomenon that is induced by repeated injections of PEGylated nanocarriers has already been studied in detail, there are few reports on the immune response elicited by the cross-administration of PEGylated nanocarriers. In this study, we investigated the ABC phenomenon induced by the intravenous cross-administration of various PEGylated nanocarriers, including PEGylated liposomes (PL), PEG micelles (PM), PEGylated solid lipid nanoparticles (PSLN), and PEGylated emulsions (PE), in beagle dogs. The results indicated that the magnitude of the immune response elicited by the cross-administration was in the following order (from the strongest to the weakest): PL, PE, PSLN, PM. It is specifically PEG in the brush structure that elicits a significant immune response, in both the induction phase and the effectuation phase. Furthermore, the present study suggests that there is a considerable difference between the effect of repeated injections and cross-administration, depending on the colloidal structure. This work is a preliminary investigation into the cross-administration of PEGylated nanocarriers, and our observations can have serious implications for the design of combination therapies that use PEGylated vectors. Keywords: ABC phenomenon, repeated injection, cross-administration, immune response, PEGylated nanocarriersWang CLCheng XBSu YQPei YSong YZJiao JHuang ZJMa YFDong YMYao YFan JJTa HLiu XRXu HDeng YHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3533-3545 (2015) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Wang CL Cheng XB Su YQ Pei Y Song YZ Jiao J Huang ZJ Ma YF Dong YM Yao Y Fan JJ Ta H Liu XR Xu H Deng YH Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs |
| description |
Chunling Wang,1 Xiaobo Cheng,2 Yuqing Su,1 Ying Pei,3 Yanzhi Song,1 Jiao Jiao,1 Zhenjun Huang,1 Yanfei Ma,1 Yinming Dong,1 Ying Yao,1 Jingjing Fan,1 Han Ta,1 Xinrong Liu,1 Hui Xu,1 Yihui Deng1 1College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China; 2Deli Wei Biological Technology Co, Ltd, Beijing, People’s Republic of China; 3Shenyang Women’s and Children’s Hospital, Shenyang, People’s Republic of China Abstract: The cross-administration of nanocarriers modified by poly(ethylene glycol) (PEG), named PEGylated nanocarriers, a type of combination therapy, is becoming an increasingly important method of long-term drug delivery, to decrease side effects, avoid multidrug resistance, and increase therapeutic efficacy. However, repeated injections of PEGylated nanocarriers induces the accelerated blood clearance (ABC) phenomenon, prevents long circulation, and can cause adverse effects owing to alterations in the biodistribution of the drug. Although the nature of the ABC phenomenon that is induced by repeated injections of PEGylated nanocarriers has already been studied in detail, there are few reports on the immune response elicited by the cross-administration of PEGylated nanocarriers. In this study, we investigated the ABC phenomenon induced by the intravenous cross-administration of various PEGylated nanocarriers, including PEGylated liposomes (PL), PEG micelles (PM), PEGylated solid lipid nanoparticles (PSLN), and PEGylated emulsions (PE), in beagle dogs. The results indicated that the magnitude of the immune response elicited by the cross-administration was in the following order (from the strongest to the weakest): PL, PE, PSLN, PM. It is specifically PEG in the brush structure that elicits a significant immune response, in both the induction phase and the effectuation phase. Furthermore, the present study suggests that there is a considerable difference between the effect of repeated injections and cross-administration, depending on the colloidal structure. This work is a preliminary investigation into the cross-administration of PEGylated nanocarriers, and our observations can have serious implications for the design of combination therapies that use PEGylated vectors. Keywords: ABC phenomenon, repeated injection, cross-administration, immune response, PEGylated nanocarriers |
| format |
article |
| author |
Wang CL Cheng XB Su YQ Pei Y Song YZ Jiao J Huang ZJ Ma YF Dong YM Yao Y Fan JJ Ta H Liu XR Xu H Deng YH |
| author_facet |
Wang CL Cheng XB Su YQ Pei Y Song YZ Jiao J Huang ZJ Ma YF Dong YM Yao Y Fan JJ Ta H Liu XR Xu H Deng YH |
| author_sort |
Wang CL |
| title |
Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs |
| title_short |
Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs |
| title_full |
Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs |
| title_fullStr |
Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs |
| title_full_unstemmed |
Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs |
| title_sort |
accelerated blood clearance phenomenon upon cross-administration of pegylated nanocarriers in beagle dogs |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/036b5345a923493fb6054721b48bfa55 |
| work_keys_str_mv |
AT wangcl acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT chengxb acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT suyq acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT peiy acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT songyz acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT jiaoj acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT huangzj acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT mayf acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT dongym acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT yaoy acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT fanjj acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT tah acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT liuxr acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT xuh acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs AT dengyh acceleratedbloodclearancephenomenonuponcrossadministrationofpegylatednanocarriersinbeagledogs |
| _version_ |
1718402081657716736 |