Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Platelets support tumor metastasis formation. Here, the authors show that the phosphoinositide signaling modulated by PITPα is essential for platelet-mediated tumor metastasis signaling, but surprisingly it is dispensable in hemostasis in mice.

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Autores principales:	Liang Zhao, Chelsea L. Thorsheim, Aae Suzuki, Timothy J. Stalker, Sang H. Min, Lurong Lian, Gregory D. Fairn, Shamshad Cockcroft, Amy Durham, Sriram Krishnaswamy, Charles S. Abrams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/036c8227c25d4741b3094639be983c32
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spelling	oai:doaj.org-article:036c8227c25d4741b3094639be983c322021-12-02T15:38:42ZPhosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis10.1038/s41467-017-01181-42041-1723https://doaj.org/article/036c8227c25d4741b3094639be983c322017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01181-4https://doaj.org/toc/2041-1723Platelets support tumor metastasis formation. Here, the authors show that the phosphoinositide signaling modulated by PITPα is essential for platelet-mediated tumor metastasis signaling, but surprisingly it is dispensable in hemostasis in mice.Liang ZhaoChelsea L. ThorsheimAae SuzukiTimothy J. StalkerSang H. MinLurong LianGregory D. FairnShamshad CockcroftAmy DurhamSriram KrishnaswamyCharles S. AbramsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liang Zhao Chelsea L. Thorsheim Aae Suzuki Timothy J. Stalker Sang H. Min Lurong Lian Gregory D. Fairn Shamshad Cockcroft Amy Durham Sriram Krishnaswamy Charles S. Abrams Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis
description	Platelets support tumor metastasis formation. Here, the authors show that the phosphoinositide signaling modulated by PITPα is essential for platelet-mediated tumor metastasis signaling, but surprisingly it is dispensable in hemostasis in mice.
format	article
author	Liang Zhao Chelsea L. Thorsheim Aae Suzuki Timothy J. Stalker Sang H. Min Lurong Lian Gregory D. Fairn Shamshad Cockcroft Amy Durham Sriram Krishnaswamy Charles S. Abrams
author_facet	Liang Zhao Chelsea L. Thorsheim Aae Suzuki Timothy J. Stalker Sang H. Min Lurong Lian Gregory D. Fairn Shamshad Cockcroft Amy Durham Sriram Krishnaswamy Charles S. Abrams
author_sort	Liang Zhao
title	Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis
title_short	Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis
title_full	Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis
title_fullStr	Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis
title_full_unstemmed	Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis
title_sort	phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/036c8227c25d4741b3094639be983c32
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Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

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