Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Platelets support tumor metastasis formation. Here, the authors show that the phosphoinositide signaling modulated by PITPα is essential for platelet-mediated tumor metastasis signaling, but surprisingly it is dispensable in hemostasis in mice.

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Detalles Bibliográficos
Autores principales: Liang Zhao, Chelsea L. Thorsheim, Aae Suzuki, Timothy J. Stalker, Sang H. Min, Lurong Lian, Gregory D. Fairn, Shamshad Cockcroft, Amy Durham, Sriram Krishnaswamy, Charles S. Abrams
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/036c8227c25d4741b3094639be983c32
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