Repellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.

The primary defence against mosquitoes and other disease vectors is often the application of a repellent. Despite their common use, the mechanism(s) underlying the activity of repellents is not fully understood, with even the mode of action of DEET having been reported to be via different mechanisms...

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Autores principales:	Gloria Isabel Jaramillo Ramirez, James G Logan, Elisa Loza-Reyes, Elena Stashenko, Graham D Moores
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/036c87ad8b354c48b9a818b531630ac7
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id	oai:doaj.org-article:036c87ad8b354c48b9a818b531630ac7
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spelling	oai:doaj.org-article:036c87ad8b354c48b9a818b531630ac72021-11-18T08:09:01ZRepellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.1932-620310.1371/journal.pone.0048698https://doaj.org/article/036c87ad8b354c48b9a818b531630ac72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23152795/?tool=EBIhttps://doaj.org/toc/1932-6203The primary defence against mosquitoes and other disease vectors is often the application of a repellent. Despite their common use, the mechanism(s) underlying the activity of repellents is not fully understood, with even the mode of action of DEET having been reported to be via different mechanisms; e.g. interference with olfactory receptor neurones or actively detected by olfactory receptor neurones on the antennae or maxillary palps. In this study, we discuss a novel mechanism for repellence, one of P450 inhibition. Thirteen essential oil extracts from Colombian plants were assayed for potency as P450 inhibitors, using a kinetic fluorometric assay, and for repellency using a modified World Health Organisation Pesticide Evaluations Scheme (WHOPES) arm-in cage assay with Stegomyia (Aedes) aegypti mosquitoes. Bootstrap analysis on the inhibition analysis revealed a significant correlation between P450-inhibition and repellent activity of the oils.Gloria Isabel Jaramillo RamirezJames G LoganElisa Loza-ReyesElena StashenkoGraham D MooresPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48698 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gloria Isabel Jaramillo Ramirez James G Logan Elisa Loza-Reyes Elena Stashenko Graham D Moores Repellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.
description	The primary defence against mosquitoes and other disease vectors is often the application of a repellent. Despite their common use, the mechanism(s) underlying the activity of repellents is not fully understood, with even the mode of action of DEET having been reported to be via different mechanisms; e.g. interference with olfactory receptor neurones or actively detected by olfactory receptor neurones on the antennae or maxillary palps. In this study, we discuss a novel mechanism for repellence, one of P450 inhibition. Thirteen essential oil extracts from Colombian plants were assayed for potency as P450 inhibitors, using a kinetic fluorometric assay, and for repellency using a modified World Health Organisation Pesticide Evaluations Scheme (WHOPES) arm-in cage assay with Stegomyia (Aedes) aegypti mosquitoes. Bootstrap analysis on the inhibition analysis revealed a significant correlation between P450-inhibition and repellent activity of the oils.
format	article
author	Gloria Isabel Jaramillo Ramirez James G Logan Elisa Loza-Reyes Elena Stashenko Graham D Moores
author_facet	Gloria Isabel Jaramillo Ramirez James G Logan Elisa Loza-Reyes Elena Stashenko Graham D Moores
author_sort	Gloria Isabel Jaramillo Ramirez
title	Repellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.
title_short	Repellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.
title_full	Repellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.
title_fullStr	Repellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.
title_full_unstemmed	Repellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.
title_sort	repellents inhibit p450 enzymes in stegomyia (aedes) aegypti.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/036c87ad8b354c48b9a818b531630ac7
work_keys_str_mv	AT gloriaisabeljaramilloramirez repellentsinhibitp450enzymesinstegomyiaaedesaegypti AT jamesglogan repellentsinhibitp450enzymesinstegomyiaaedesaegypti AT elisalozareyes repellentsinhibitp450enzymesinstegomyiaaedesaegypti AT elenastashenko repellentsinhibitp450enzymesinstegomyiaaedesaegypti AT grahamdmoores repellentsinhibitp450enzymesinstegomyiaaedesaegypti
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Repellents inhibit P450 enzymes in Stegomyia (Aedes) aegypti.

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