Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment

Aims. To study the dynamics of body weight, waist circumference, blood lipid and insulin demand in patients with type 2 diabetes mellitus (T2DM) during first year of combined treatment with metformin and insulin analogues, compared with insulin analogue monotherapy. Materials and Methods. We exami...

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Autores principales:	Tatiana Ivanovna Romantsova, T Sh Dzhavakhishvili, O V Roik
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	diabetes mellitus type 2 insulin therapy insulin analogues metformin Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/036d8227a68a44eca926ab8e0dc1657b
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spelling	oai:doaj.org-article:036d8227a68a44eca926ab8e0dc1657b2021-11-14T09:00:18ZEffects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment2072-03512072-037810.14341/2072-0351-3596https://doaj.org/article/036d8227a68a44eca926ab8e0dc1657b2013-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3596https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. To study the dynamics of body weight, waist circumference, blood lipid and insulin demand in patients with type 2 diabetes mellitus (T2DM) during first year of combined treatment with metformin and insulin analogues, compared with insulin analogue monotherapy. Materials and Methods. We examined 78 patients with T2DM on newly initiated insulin therapy, including 54 females and 24 males. Median age was 56 [51.0; 64.0] years, median disease duration ? 9 [6.8;14.0] years. Participants were subdivided in two groups. First group was comprised of 48 subjects (33 females and 15 males), who received monotherapy with insulin analogues (glargine, de- temir, biphasic Aspart 30 and Humalog Mix 25 or rapid-acting lispro and aspart). Second group included 30 patients (18 females and12 males), who were treated with combined therapy (insulin analogues plus metformin). We measured HbA1c, plasma lipid composition, BMI, waist circumference and insulin demand initially and after one year of follow-up. Results. We showed that combined therapy vs. insulin monotherapy allows better glycemic compensation while reducing insulin demand and lowering risks for weight gain. Conclusions. Combined insulin analogue plus metformin treatment delivers better metabolic control in patients with T2DM and is as- sociated with lower risks for body weight gain and increase in insulin demand against monotherapy with insulin analogues.Tatiana Ivanovna RomantsovaT Sh DzhavakhishviliO V RoikEndocrinology Research Centrearticlediabetes mellitus type 2insulin therapyinsulin analoguesmetforminNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 1, Pp 48-51 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 2 insulin therapy insulin analogues metformin Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 2 insulin therapy insulin analogues metformin Nutritional diseases. Deficiency diseases RC620-627 Tatiana Ivanovna Romantsova T Sh Dzhavakhishvili O V Roik Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment
description	Aims. To study the dynamics of body weight, waist circumference, blood lipid and insulin demand in patients with type 2 diabetes mellitus (T2DM) during first year of combined treatment with metformin and insulin analogues, compared with insulin analogue monotherapy. Materials and Methods. We examined 78 patients with T2DM on newly initiated insulin therapy, including 54 females and 24 males. Median age was 56 [51.0; 64.0] years, median disease duration ? 9 [6.8;14.0] years. Participants were subdivided in two groups. First group was comprised of 48 subjects (33 females and 15 males), who received monotherapy with insulin analogues (glargine, de- temir, biphasic Aspart 30 and Humalog Mix 25 or rapid-acting lispro and aspart). Second group included 30 patients (18 females and12 males), who were treated with combined therapy (insulin analogues plus metformin). We measured HbA1c, plasma lipid composition, BMI, waist circumference and insulin demand initially and after one year of follow-up. Results. We showed that combined therapy vs. insulin monotherapy allows better glycemic compensation while reducing insulin demand and lowering risks for weight gain. Conclusions. Combined insulin analogue plus metformin treatment delivers better metabolic control in patients with T2DM and is as- sociated with lower risks for body weight gain and increase in insulin demand against monotherapy with insulin analogues.
format	article
author	Tatiana Ivanovna Romantsova T Sh Dzhavakhishvili O V Roik
author_facet	Tatiana Ivanovna Romantsova T Sh Dzhavakhishvili O V Roik
author_sort	Tatiana Ivanovna Romantsova
title	Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment
title_short	Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment
title_full	Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment
title_fullStr	Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment
title_full_unstemmed	Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment
title_sort	effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/036d8227a68a44eca926ab8e0dc1657b
work_keys_str_mv	AT tatianaivanovnaromantsova effectsofmetforminonbodyweightinpatientswithtype2diabetesmellitusreceivinginsulinanaloguetreatment AT tshdzhavakhishvili effectsofmetforminonbodyweightinpatientswithtype2diabetesmellitusreceivinginsulinanaloguetreatment AT ovroik effectsofmetforminonbodyweightinpatientswithtype2diabetesmellitusreceivinginsulinanaloguetreatment
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Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment

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