ACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS

The creation of immuno-biological drugs to increase the effectiveness of specific immunotherapy and immunoprophylaxis is a current trend in medicine to date. Therefore, the search and development of new safe and effective artificial bioorganic complexes (immunomodulators) capable of stimulating indi...

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Autores principales:	V. I. Dubrovina, S. A. Vityazeva, K. M. Korytov, A. B. Pyatidesyatnikova, V. V. Voytkova, G. F. Prozorova, A. S. Pozdnyakov, A. A. Ivanova, S. V. Balakhonov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	copolymer 1-vinyl-1 2 4-triazole with n-vinylpyrroledone nanocomposite phagocyte cell of blood cytokine Science Q
Acceso en línea:	https://doaj.org/article/036e279379d74eb09db7bf9bc9db1d62
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spelling	oai:doaj.org-article:036e279379d74eb09db7bf9bc9db1d622021-11-23T06:14:41ZACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS2541-94202587-959610.29413/ABS.2018-3.5.19https://doaj.org/article/036e279379d74eb09db7bf9bc9db1d622018-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/718https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The creation of immuno-biological drugs to increase the effectiveness of specific immunotherapy and immunoprophylaxis is a current trend in medicine to date. Therefore, the search and development of new safe and effective artificial bioorganic complexes (immunomodulators) capable of stimulating individual responses of immune system to reduce infectious morbidity is an important area of research. At the moment, such promising preparations can be considered water-soluble polymeric materials and organo-inorganic polymer nanocomposites with nanoparticles of various metals which possess immunomodulating and bactericidal properties. The study results of the effects of 1-vinyl-1,2,4-triazole copolymer with N-vinylpyrrolidone and nanocomposites based on it with gold and silver nanoparticles on acute toxicity and functional state of immunophagocytic cells of experimental animals, as well as the production of IFN-γ, TNF-α and IL-4 by human blood lymphocytes are represented in this article. It was established that the tested preparations do not cause increase in body temperature, decrease in mass and death of animals. It was shown that they also have the multidirectional action on cytokine production by human blood cells in vitro, the ability to increase activity of оxidative stress-related enzymes and antioxidant protection of phagocytes. The data obtained by us allow to explain the need for further investigation of the actions of nanocomposites and copolymer in vitro and in vivo.V. I. DubrovinaS. A. VityazevaK. M. KorytovA. B. PyatidesyatnikovaV. V. VoytkovaG. F. ProzorovaA. S. PozdnyakovA. A. IvanovaS. V. BalakhonovScientific Сentre for Family Health and Human Reproduction Problemsarticlecopolymer1-vinyl-124-triazole with n-vinylpyrroledonenanocompositephagocytecell of bloodcytokineScienceQRUActa Biomedica Scientifica, Vol 3, Iss 5, Pp 132-136 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	copolymer 1-vinyl-1 2 4-triazole with n-vinylpyrroledone nanocomposite phagocyte cell of blood cytokine Science Q
spellingShingle	copolymer 1-vinyl-1 2 4-triazole with n-vinylpyrroledone nanocomposite phagocyte cell of blood cytokine Science Q V. I. Dubrovina S. A. Vityazeva K. M. Korytov A. B. Pyatidesyatnikova V. V. Voytkova G. F. Prozorova A. S. Pozdnyakov A. A. Ivanova S. V. Balakhonov ACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS
description	The creation of immuno-biological drugs to increase the effectiveness of specific immunotherapy and immunoprophylaxis is a current trend in medicine to date. Therefore, the search and development of new safe and effective artificial bioorganic complexes (immunomodulators) capable of stimulating individual responses of immune system to reduce infectious morbidity is an important area of research. At the moment, such promising preparations can be considered water-soluble polymeric materials and organo-inorganic polymer nanocomposites with nanoparticles of various metals which possess immunomodulating and bactericidal properties. The study results of the effects of 1-vinyl-1,2,4-triazole copolymer with N-vinylpyrrolidone and nanocomposites based on it with gold and silver nanoparticles on acute toxicity and functional state of immunophagocytic cells of experimental animals, as well as the production of IFN-γ, TNF-α and IL-4 by human blood lymphocytes are represented in this article. It was established that the tested preparations do not cause increase in body temperature, decrease in mass and death of animals. It was shown that they also have the multidirectional action on cytokine production by human blood cells in vitro, the ability to increase activity of оxidative stress-related enzymes and antioxidant protection of phagocytes. The data obtained by us allow to explain the need for further investigation of the actions of nanocomposites and copolymer in vitro and in vivo.
format	article
author	V. I. Dubrovina S. A. Vityazeva K. M. Korytov A. B. Pyatidesyatnikova V. V. Voytkova G. F. Prozorova A. S. Pozdnyakov A. A. Ivanova S. V. Balakhonov
author_facet	V. I. Dubrovina S. A. Vityazeva K. M. Korytov A. B. Pyatidesyatnikova V. V. Voytkova G. F. Prozorova A. S. Pozdnyakov A. A. Ivanova S. V. Balakhonov
author_sort	V. I. Dubrovina
title	ACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS
title_short	ACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS
title_full	ACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS
title_fullStr	ACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS
title_full_unstemmed	ACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS
title_sort	action of 1-vinyl-1,2,4-triazole copolymer with n-vinylpirolidone and metal-containing nanocomposites on functional state of phagocytic cells
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/036e279379d74eb09db7bf9bc9db1d62
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_version_	1718416924290842624

ACTION OF 1-VINYL-1,2,4-TRIAZOLE COPOLYMER WITH N-VINYLPIROLIDONE AND METAL-CONTAINING NANOCOMPOSITES ON FUNCTIONAL STATE OF PHAGOCYTIC CELLS

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