CD13 orients the apical-basal polarity axis necessary for lumen formation

Epithelial cells that organise into structures that contain a lumen are polarised. Here, the authors show that the short intracellular domain of transmembrane protein CD13 is required to capture endosomes at the apical site and is required for the polarisation of cells.

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Detalles Bibliográficos
Autores principales:	Li-Ting Wang, Abira Rajah, Claire M. Brown, Luke McCaffrey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/036f5b17608448fa948f9d7a338d3066
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spelling	oai:doaj.org-article:036f5b17608448fa948f9d7a338d30662021-12-02T18:49:22ZCD13 orients the apical-basal polarity axis necessary for lumen formation10.1038/s41467-021-24993-x2041-1723https://doaj.org/article/036f5b17608448fa948f9d7a338d30662021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24993-xhttps://doaj.org/toc/2041-1723Epithelial cells that organise into structures that contain a lumen are polarised. Here, the authors show that the short intracellular domain of transmembrane protein CD13 is required to capture endosomes at the apical site and is required for the polarisation of cells.Li-Ting WangAbira RajahClaire M. BrownLuke McCaffreyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li-Ting Wang Abira Rajah Claire M. Brown Luke McCaffrey CD13 orients the apical-basal polarity axis necessary for lumen formation
description	Epithelial cells that organise into structures that contain a lumen are polarised. Here, the authors show that the short intracellular domain of transmembrane protein CD13 is required to capture endosomes at the apical site and is required for the polarisation of cells.
format	article
author	Li-Ting Wang Abira Rajah Claire M. Brown Luke McCaffrey
author_facet	Li-Ting Wang Abira Rajah Claire M. Brown Luke McCaffrey
author_sort	Li-Ting Wang
title	CD13 orients the apical-basal polarity axis necessary for lumen formation
title_short	CD13 orients the apical-basal polarity axis necessary for lumen formation
title_full	CD13 orients the apical-basal polarity axis necessary for lumen formation
title_fullStr	CD13 orients the apical-basal polarity axis necessary for lumen formation
title_full_unstemmed	CD13 orients the apical-basal polarity axis necessary for lumen formation
title_sort	cd13 orients the apical-basal polarity axis necessary for lumen formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/036f5b17608448fa948f9d7a338d3066
work_keys_str_mv	AT litingwang cd13orientstheapicalbasalpolarityaxisnecessaryforlumenformation AT abirarajah cd13orientstheapicalbasalpolarityaxisnecessaryforlumenformation AT clairembrown cd13orientstheapicalbasalpolarityaxisnecessaryforlumenformation AT lukemccaffrey cd13orientstheapicalbasalpolarityaxisnecessaryforlumenformation
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CD13 orients the apical-basal polarity axis necessary for lumen formation

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