KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.

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Detalles Bibliográficos
Autores principales: Anqi Geng, Runxiang Qiu, Kiyohito Murai, Jiancheng Liu, Xiwei Wu, Heying Zhang, Henry Farhoodi, Nam Duong, Meisheng Jiang, Jiing-kuan Yee, Walter Tsark, Qiang Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0376cb29837141ebabd45e872751324b
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Sumario:The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.