KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Anqi Geng, Runxiang Qiu, Kiyohito Murai, Jiancheng Liu, Xiwei Wu, Heying Zhang, Henry Farhoodi, Nam Duong, Meisheng Jiang, Jiing-kuan Yee, Walter Tsark, Qiang Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0376cb29837141ebabd45e872751324b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0376cb29837141ebabd45e872751324b
record_format	dspace
spelling	oai:doaj.org-article:0376cb29837141ebabd45e872751324b2021-12-02T14:40:43ZKIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development10.1038/s41467-018-05152-12041-1723https://doaj.org/article/0376cb29837141ebabd45e872751324b2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05152-1https://doaj.org/toc/2041-1723The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.Anqi GengRunxiang QiuKiyohito MuraiJiancheng LiuXiwei WuHeying ZhangHenry FarhoodiNam DuongMeisheng JiangJiing-kuan YeeWalter TsarkQiang LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anqi Geng Runxiang Qiu Kiyohito Murai Jiancheng Liu Xiwei Wu Heying Zhang Henry Farhoodi Nam Duong Meisheng Jiang Jiing-kuan Yee Walter Tsark Qiang Lu KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
description	The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.
format	article
author	Anqi Geng Runxiang Qiu Kiyohito Murai Jiancheng Liu Xiwei Wu Heying Zhang Henry Farhoodi Nam Duong Meisheng Jiang Jiing-kuan Yee Walter Tsark Qiang Lu
author_facet	Anqi Geng Runxiang Qiu Kiyohito Murai Jiancheng Liu Xiwei Wu Heying Zhang Henry Farhoodi Nam Duong Meisheng Jiang Jiing-kuan Yee Walter Tsark Qiang Lu
author_sort	Anqi Geng
title	KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
title_short	KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
title_full	KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
title_fullStr	KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
title_full_unstemmed	KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
title_sort	kif20a/mklp2 regulates the division modes of neural progenitor cells during cortical development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0376cb29837141ebabd45e872751324b
work_keys_str_mv	AT anqigeng kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT runxiangqiu kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT kiyohitomurai kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT jianchengliu kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT xiweiwu kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT heyingzhang kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT henryfarhoodi kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT namduong kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT meishengjiang kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT jiingkuanyee kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT waltertsark kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment AT qianglu kif20amklp2regulatesthedivisionmodesofneuralprogenitorcellsduringcorticaldevelopment
_version_	1718390152236105728

KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

Ejemplares similares