Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model

Treatment of neuropathic pain is far from satisfactory. This study sought evidence of a neuroprotective effect of alpha-lipoic acid (ALA) to treat neuropathic pain in a chronic constriction injury (CCI) rat model. A total of 48 rats were randomly divided into sham, CCI, or CCI + ALA groups. Mechanic...

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Autores principales:	Wang Junhao, Lou Zhaohui, Xi Haiyang, Li Zhi, Li Lepeng, Li Zhenzhen, Zhang Kai, Asakawa Tetsuya
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	neuropathic pain peripheral nerve injury alpha-lipoic acid satellite glial cells dorsal root ganglia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/03772240d3eb48b6b0d64264a7dd9e9f
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spelling	oai:doaj.org-article:03772240d3eb48b6b0d64264a7dd9e9f2021-12-05T14:10:40ZVerification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model2391-541210.1515/biol-2021-0026https://doaj.org/article/03772240d3eb48b6b0d64264a7dd9e9f2021-03-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0026https://doaj.org/toc/2391-5412Treatment of neuropathic pain is far from satisfactory. This study sought evidence of a neuroprotective effect of alpha-lipoic acid (ALA) to treat neuropathic pain in a chronic constriction injury (CCI) rat model. A total of 48 rats were randomly divided into sham, CCI, or CCI + ALA groups. Mechanical and thermal nociceptive thresholds were evaluated as behavioral assessments. Dorsal root ganglia cells were assessed morphologically with hematoxylin and eosin staining and for apoptosis with P53 immunohistochemical staining. Compared with the sham group, the CCI group had a shorter paw withdrawal threshold and paw withdrawal latency, abnormal morphologic manifestations, and increased numbers of satellite glial cells and P53+ cells. These changes were significantly reversed by treatment with ALA. Our study indicates neuroprotective effects of ALA on chronic neuropathic pain in a CCI rat model. ALA is potentially considered to be developed as a treatment for neuropathic pain caused by peripheral nerve injury, which requires further verification.Wang JunhaoLou ZhaohuiXi HaiyangLi ZhiLi LepengLi ZhenzhenZhang KaiAsakawa TetsuyaDe Gruyterarticleneuropathic painperipheral nerve injuryalpha-lipoic acidsatellite glial cellsdorsal root gangliaBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 222-228 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuropathic pain peripheral nerve injury alpha-lipoic acid satellite glial cells dorsal root ganglia Biology (General) QH301-705.5
spellingShingle	neuropathic pain peripheral nerve injury alpha-lipoic acid satellite glial cells dorsal root ganglia Biology (General) QH301-705.5 Wang Junhao Lou Zhaohui Xi Haiyang Li Zhi Li Lepeng Li Zhenzhen Zhang Kai Asakawa Tetsuya Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
description	Treatment of neuropathic pain is far from satisfactory. This study sought evidence of a neuroprotective effect of alpha-lipoic acid (ALA) to treat neuropathic pain in a chronic constriction injury (CCI) rat model. A total of 48 rats were randomly divided into sham, CCI, or CCI + ALA groups. Mechanical and thermal nociceptive thresholds were evaluated as behavioral assessments. Dorsal root ganglia cells were assessed morphologically with hematoxylin and eosin staining and for apoptosis with P53 immunohistochemical staining. Compared with the sham group, the CCI group had a shorter paw withdrawal threshold and paw withdrawal latency, abnormal morphologic manifestations, and increased numbers of satellite glial cells and P53+ cells. These changes were significantly reversed by treatment with ALA. Our study indicates neuroprotective effects of ALA on chronic neuropathic pain in a CCI rat model. ALA is potentially considered to be developed as a treatment for neuropathic pain caused by peripheral nerve injury, which requires further verification.
format	article
author	Wang Junhao Lou Zhaohui Xi Haiyang Li Zhi Li Lepeng Li Zhenzhen Zhang Kai Asakawa Tetsuya
author_facet	Wang Junhao Lou Zhaohui Xi Haiyang Li Zhi Li Lepeng Li Zhenzhen Zhang Kai Asakawa Tetsuya
author_sort	Wang Junhao
title	Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
title_short	Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
title_full	Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
title_fullStr	Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
title_full_unstemmed	Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
title_sort	verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/03772240d3eb48b6b0d64264a7dd9e9f
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Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model

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