HIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis

Summary: Background: Transgender women (TW) in Peru are disproportionately affected by HIV. The role that cisgender men who have sex with TW (MSTW) and their sexual networks play in TW's risk of acquiring HIV is not well understood. We used HIV sequences from TW, MSTW, and cisgender men who ha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jessica E. Long, Diana M. Tordoff, Sari L. Reisner, Sayan Dasgupta, Kenneth H. Mayer, James I. Mullins, Javier R. Lama, Joshua T. Herbeck, Ann Duerr
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/0378a64952ee4e9d9d5baa07a00ea65b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0378a64952ee4e9d9d5baa07a00ea65b
record_format	dspace
spelling	oai:doaj.org-article:0378a64952ee4e9d9d5baa07a00ea65b2021-12-02T05:04:43ZHIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis2667-193X10.1016/j.lana.2021.100121https://doaj.org/article/0378a64952ee4e9d9d5baa07a00ea65b2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667193X21001174https://doaj.org/toc/2667-193XSummary: Background: Transgender women (TW) in Peru are disproportionately affected by HIV. The role that cisgender men who have sex with TW (MSTW) and their sexual networks play in TW's risk of acquiring HIV is not well understood. We used HIV sequences from TW, MSTW, and cisgender men who have sex with men (MSM) to examine transmission dynamics between these groups. Methods: We used HIV-1 pol sequences and epidemiologic data collected through three Lima-based studies from 2013 to 2018 (n = 139 TW, n = 25 MSTW, n = 303 MSM). We identified molecular clusters based on pairwise genetic distance and used structured coalescent phylodynamic modeling to estimate transmission patterns between groups. Findings: Among 200 participants (43%) found in 62 clusters, the probability of clustering did not differ by group. Both MSM and TW were more likely to cluster with members of their own group than would be expected based on random mixing. Phylodynamic modeling estimated that there was frequent transmission from MSTW to TW (67·9% of transmission from MSTW; 95%CI = 52·8–83·2%) and from TW to MSTW (76·5% of transmissions from TW; 95%CI = 65·5–90·3%). HIV transmission between MSM and TW was estimated to comprise a small proportion of overall transmissions (4·9% of transmissions from MSM, and 11·8% of transmissions from TW), as were transmissions between MSM and MSTW (7·2% of transmissions from MSM, and 32·0% of transmissions from MSTW). Interpretation: These results provide quantitative evidence that MSTW play an important role in TW's HIV vulnerability and that MSTW have an HIV transmission network that is largely distinct from MSM. Funding: National Institutes of Health.Jessica E. LongDiana M. TordoffSari L. ReisnerSayan DasguptaKenneth H. MayerJames I. MullinsJavier R. LamaJoshua T. HerbeckAnn DuerrElsevierarticlePublic aspects of medicineRA1-1270ENThe Lancet Regional Health. Americas, Vol 6, Iss , Pp 100121- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Public aspects of medicine RA1-1270
spellingShingle	Public aspects of medicine RA1-1270 Jessica E. Long Diana M. Tordoff Sari L. Reisner Sayan Dasgupta Kenneth H. Mayer James I. Mullins Javier R. Lama Joshua T. Herbeck Ann Duerr HIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis
description	Summary: Background: Transgender women (TW) in Peru are disproportionately affected by HIV. The role that cisgender men who have sex with TW (MSTW) and their sexual networks play in TW's risk of acquiring HIV is not well understood. We used HIV sequences from TW, MSTW, and cisgender men who have sex with men (MSM) to examine transmission dynamics between these groups. Methods: We used HIV-1 pol sequences and epidemiologic data collected through three Lima-based studies from 2013 to 2018 (n = 139 TW, n = 25 MSTW, n = 303 MSM). We identified molecular clusters based on pairwise genetic distance and used structured coalescent phylodynamic modeling to estimate transmission patterns between groups. Findings: Among 200 participants (43%) found in 62 clusters, the probability of clustering did not differ by group. Both MSM and TW were more likely to cluster with members of their own group than would be expected based on random mixing. Phylodynamic modeling estimated that there was frequent transmission from MSTW to TW (67·9% of transmission from MSTW; 95%CI = 52·8–83·2%) and from TW to MSTW (76·5% of transmissions from TW; 95%CI = 65·5–90·3%). HIV transmission between MSM and TW was estimated to comprise a small proportion of overall transmissions (4·9% of transmissions from MSM, and 11·8% of transmissions from TW), as were transmissions between MSM and MSTW (7·2% of transmissions from MSM, and 32·0% of transmissions from MSTW). Interpretation: These results provide quantitative evidence that MSTW play an important role in TW's HIV vulnerability and that MSTW have an HIV transmission network that is largely distinct from MSM. Funding: National Institutes of Health.
format	article
author	Jessica E. Long Diana M. Tordoff Sari L. Reisner Sayan Dasgupta Kenneth H. Mayer James I. Mullins Javier R. Lama Joshua T. Herbeck Ann Duerr
author_facet	Jessica E. Long Diana M. Tordoff Sari L. Reisner Sayan Dasgupta Kenneth H. Mayer James I. Mullins Javier R. Lama Joshua T. Herbeck Ann Duerr
author_sort	Jessica E. Long
title	HIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis
title_short	HIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis
title_full	HIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis
title_fullStr	HIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis
title_full_unstemmed	HIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis
title_sort	hiv transmission patterns among transgender women, their cisgender male partners, and cisgender msm in lima, peru: a molecular epidemiologic and phylodynamic analysis
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/0378a64952ee4e9d9d5baa07a00ea65b
work_keys_str_mv	AT jessicaelong hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis AT dianamtordoff hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis AT sarilreisner hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis AT sayandasgupta hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis AT kennethhmayer hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis AT jamesimullins hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis AT javierrlama hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis AT joshuatherbeck hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis AT annduerr hivtransmissionpatternsamongtransgenderwomentheircisgendermalepartnersandcisgendermsminlimaperuamolecularepidemiologicandphylodynamicanalysis
_version_	1718400571345469440

HIV transmission patterns among transgender women, their cisgender male partners, and cisgender MSM in Lima, Peru: A molecular epidemiologic and phylodynamic analysis

Ejemplares similares