Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing
Chemical modification of proteins can be used to decipher function or use that function for therapeutic purposes. Here, the authors insert synthetic peptides via tandem protein trans-splicing to add post-translational modifications or non-canonical amino acids.
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Nature Portfolio
2020
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oai:doaj.org-article:037b70cf2f134b59a04bb9e43a7e60752021-12-02T14:41:12ZChemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing10.1038/s41467-020-16208-62041-1723https://doaj.org/article/037b70cf2f134b59a04bb9e43a7e60752020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16208-6https://doaj.org/toc/2041-1723Chemical modification of proteins can be used to decipher function or use that function for therapeutic purposes. Here, the authors insert synthetic peptides via tandem protein trans-splicing to add post-translational modifications or non-canonical amino acids.K. K. KhooI. GalleanoF. GasparriR. WienekeH. HarmsM. H. PoulsenH. C. ChuaM. WulfR. TampéS. A. PlessNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
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Science Q K. K. Khoo I. Galleano F. Gasparri R. Wieneke H. Harms M. H. Poulsen H. C. Chua M. Wulf R. Tampé S. A. Pless Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing |
description |
Chemical modification of proteins can be used to decipher function or use that function for therapeutic purposes. Here, the authors insert synthetic peptides via tandem protein trans-splicing to add post-translational modifications or non-canonical amino acids. |
format |
article |
author |
K. K. Khoo I. Galleano F. Gasparri R. Wieneke H. Harms M. H. Poulsen H. C. Chua M. Wulf R. Tampé S. A. Pless |
author_facet |
K. K. Khoo I. Galleano F. Gasparri R. Wieneke H. Harms M. H. Poulsen H. C. Chua M. Wulf R. Tampé S. A. Pless |
author_sort |
K. K. Khoo |
title |
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing |
title_short |
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing |
title_full |
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing |
title_fullStr |
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing |
title_full_unstemmed |
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing |
title_sort |
chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/037b70cf2f134b59a04bb9e43a7e6075 |
work_keys_str_mv |
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1718389970697191424 |