Adipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder

Signet ring cell morphology may result from a variety of causes and ranges from a benign reactive phenomenon to being indicative of highly aggressive malignancy. Benign epithelial signet ring cell change is well described in a variety of tissues, but nonepithelial signet ring cell change is a rare m...

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Autores principales:	Benjamin van Haeringen, Leo Francis, Emily Olive, Daniel James
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Pathology RB1-214
Acceso en línea:	https://doaj.org/article/037dd014f4034decb9b40cebab9bcc99
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spelling	oai:doaj.org-article:037dd014f4034decb9b40cebab9bcc992021-11-08T02:36:04ZAdipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder2090-679X10.1155/2021/4676885https://doaj.org/article/037dd014f4034decb9b40cebab9bcc992021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4676885https://doaj.org/toc/2090-679XSignet ring cell morphology may result from a variety of causes and ranges from a benign reactive phenomenon to being indicative of highly aggressive malignancy. Benign epithelial signet ring cell change is well described in a variety of tissues, but nonepithelial signet ring cell change is a rare morphologic adaptation of adipose tissue principally described in the setting of cachexia. The location of these atrophic adipocytes outside the plane of normal epithelial layers may raise concern for invasive or metastatic malignancy, and consideration of a benign reactive process is critical to avoid catastrophic overdiagnosis and overtreatment. Further, this change is itself associated with significant mortality related to the underlying cachexia and may be important to highlight to treating clinicians. Compared to malignant signet ring cell carcinoma, benign signet ring cell change is more likely to retain normal lobulated architecture without mass formation, lack significant atypia, have myxoid stroma with a prominent capillary network, and show positive staining S100 protein with negative staining for cytokeratins and mucin. To our knowledge, we present the first described case of nonepithelial signet ring cell change involving the gallbladder, detected as an incidental finding following routine cholecystectomy in an elderly cachectic man.Benjamin van HaeringenLeo FrancisEmily OliveDaniel JamesHindawi LimitedarticlePathologyRB1-214ENCase Reports in Pathology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214
spellingShingle	Pathology RB1-214 Benjamin van Haeringen Leo Francis Emily Olive Daniel James Adipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder
description	Signet ring cell morphology may result from a variety of causes and ranges from a benign reactive phenomenon to being indicative of highly aggressive malignancy. Benign epithelial signet ring cell change is well described in a variety of tissues, but nonepithelial signet ring cell change is a rare morphologic adaptation of adipose tissue principally described in the setting of cachexia. The location of these atrophic adipocytes outside the plane of normal epithelial layers may raise concern for invasive or metastatic malignancy, and consideration of a benign reactive process is critical to avoid catastrophic overdiagnosis and overtreatment. Further, this change is itself associated with significant mortality related to the underlying cachexia and may be important to highlight to treating clinicians. Compared to malignant signet ring cell carcinoma, benign signet ring cell change is more likely to retain normal lobulated architecture without mass formation, lack significant atypia, have myxoid stroma with a prominent capillary network, and show positive staining S100 protein with negative staining for cytokeratins and mucin. To our knowledge, we present the first described case of nonepithelial signet ring cell change involving the gallbladder, detected as an incidental finding following routine cholecystectomy in an elderly cachectic man.
format	article
author	Benjamin van Haeringen Leo Francis Emily Olive Daniel James
author_facet	Benjamin van Haeringen Leo Francis Emily Olive Daniel James
author_sort	Benjamin van Haeringen
title	Adipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder
title_short	Adipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder
title_full	Adipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder
title_fullStr	Adipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder
title_full_unstemmed	Adipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder
title_sort	adipocyte atrophy mimicking signet ring cell carcinoma of the gallbladder
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/037dd014f4034decb9b40cebab9bcc99
work_keys_str_mv	AT benjaminvanhaeringen adipocyteatrophymimickingsignetringcellcarcinomaofthegallbladder AT leofrancis adipocyteatrophymimickingsignetringcellcarcinomaofthegallbladder AT emilyolive adipocyteatrophymimickingsignetringcellcarcinomaofthegallbladder AT danieljames adipocyteatrophymimickingsignetringcellcarcinomaofthegallbladder
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Adipocyte Atrophy Mimicking Signet Ring Cell Carcinoma of the Gallbladder

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