Somatic SF3B1 hotspot mutation in prolactinomas

The genetic basis of prolactinomas remains poorly understood. Here, the authors find a recurrent hotspot somatic mutation in the splicing factor 3 subunit B1 (SF3B1 R625H ) in prolactinomas, and show that this mutation causes aberrant splicing of ESRRG mRNA leading to up-regulation of prolactin.

Guardado en:

Detalles Bibliográficos
Autores principales:	Chuzhong Li, Weiyan Xie, Jared S. Rosenblum, Jianyu Zhou, Jing Guo, Yazhou Miao, Yutao Shen, Hongyun Wang, Lei Gong, Mingxuan Li, Sida Zhao, Sen Cheng, Haibo Zhu, Tao Jiang, Shiying Ling, Fei Wang, Hongwei Zhang, Mingshan Zhang, Yanming Qu, Qi Zhang, Guilin Li, Junmei Wang, Jun Ma, Zhengping Zhuang, Yazhuo Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03819aa8e3fa4e1cb3bc7de1641abf1b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03819aa8e3fa4e1cb3bc7de1641abf1b
record_format	dspace
spelling	oai:doaj.org-article:03819aa8e3fa4e1cb3bc7de1641abf1b2021-12-02T15:45:24ZSomatic SF3B1 hotspot mutation in prolactinomas10.1038/s41467-020-16052-82041-1723https://doaj.org/article/03819aa8e3fa4e1cb3bc7de1641abf1b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16052-8https://doaj.org/toc/2041-1723The genetic basis of prolactinomas remains poorly understood. Here, the authors find a recurrent hotspot somatic mutation in the splicing factor 3 subunit B1 (SF3B1 R625H ) in prolactinomas, and show that this mutation causes aberrant splicing of ESRRG mRNA leading to up-regulation of prolactin.Chuzhong LiWeiyan XieJared S. RosenblumJianyu ZhouJing GuoYazhou MiaoYutao ShenHongyun WangLei GongMingxuan LiSida ZhaoSen ChengHaibo ZhuTao JiangShiying LingFei WangHongwei ZhangMingshan ZhangYanming QuQi ZhangGuilin LiJunmei WangJun MaZhengping ZhuangYazhuo ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chuzhong Li Weiyan Xie Jared S. Rosenblum Jianyu Zhou Jing Guo Yazhou Miao Yutao Shen Hongyun Wang Lei Gong Mingxuan Li Sida Zhao Sen Cheng Haibo Zhu Tao Jiang Shiying Ling Fei Wang Hongwei Zhang Mingshan Zhang Yanming Qu Qi Zhang Guilin Li Junmei Wang Jun Ma Zhengping Zhuang Yazhuo Zhang Somatic SF3B1 hotspot mutation in prolactinomas
description	The genetic basis of prolactinomas remains poorly understood. Here, the authors find a recurrent hotspot somatic mutation in the splicing factor 3 subunit B1 (SF3B1 R625H ) in prolactinomas, and show that this mutation causes aberrant splicing of ESRRG mRNA leading to up-regulation of prolactin.
format	article
author	Chuzhong Li Weiyan Xie Jared S. Rosenblum Jianyu Zhou Jing Guo Yazhou Miao Yutao Shen Hongyun Wang Lei Gong Mingxuan Li Sida Zhao Sen Cheng Haibo Zhu Tao Jiang Shiying Ling Fei Wang Hongwei Zhang Mingshan Zhang Yanming Qu Qi Zhang Guilin Li Junmei Wang Jun Ma Zhengping Zhuang Yazhuo Zhang
author_facet	Chuzhong Li Weiyan Xie Jared S. Rosenblum Jianyu Zhou Jing Guo Yazhou Miao Yutao Shen Hongyun Wang Lei Gong Mingxuan Li Sida Zhao Sen Cheng Haibo Zhu Tao Jiang Shiying Ling Fei Wang Hongwei Zhang Mingshan Zhang Yanming Qu Qi Zhang Guilin Li Junmei Wang Jun Ma Zhengping Zhuang Yazhuo Zhang
author_sort	Chuzhong Li
title	Somatic SF3B1 hotspot mutation in prolactinomas
title_short	Somatic SF3B1 hotspot mutation in prolactinomas
title_full	Somatic SF3B1 hotspot mutation in prolactinomas
title_fullStr	Somatic SF3B1 hotspot mutation in prolactinomas
title_full_unstemmed	Somatic SF3B1 hotspot mutation in prolactinomas
title_sort	somatic sf3b1 hotspot mutation in prolactinomas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/03819aa8e3fa4e1cb3bc7de1641abf1b
work_keys_str_mv	AT chuzhongli somaticsf3b1hotspotmutationinprolactinomas AT weiyanxie somaticsf3b1hotspotmutationinprolactinomas AT jaredsrosenblum somaticsf3b1hotspotmutationinprolactinomas AT jianyuzhou somaticsf3b1hotspotmutationinprolactinomas AT jingguo somaticsf3b1hotspotmutationinprolactinomas AT yazhoumiao somaticsf3b1hotspotmutationinprolactinomas AT yutaoshen somaticsf3b1hotspotmutationinprolactinomas AT hongyunwang somaticsf3b1hotspotmutationinprolactinomas AT leigong somaticsf3b1hotspotmutationinprolactinomas AT mingxuanli somaticsf3b1hotspotmutationinprolactinomas AT sidazhao somaticsf3b1hotspotmutationinprolactinomas AT sencheng somaticsf3b1hotspotmutationinprolactinomas AT haibozhu somaticsf3b1hotspotmutationinprolactinomas AT taojiang somaticsf3b1hotspotmutationinprolactinomas AT shiyingling somaticsf3b1hotspotmutationinprolactinomas AT feiwang somaticsf3b1hotspotmutationinprolactinomas AT hongweizhang somaticsf3b1hotspotmutationinprolactinomas AT mingshanzhang somaticsf3b1hotspotmutationinprolactinomas AT yanmingqu somaticsf3b1hotspotmutationinprolactinomas AT qizhang somaticsf3b1hotspotmutationinprolactinomas AT guilinli somaticsf3b1hotspotmutationinprolactinomas AT junmeiwang somaticsf3b1hotspotmutationinprolactinomas AT junma somaticsf3b1hotspotmutationinprolactinomas AT zhengpingzhuang somaticsf3b1hotspotmutationinprolactinomas AT yazhuozhang somaticsf3b1hotspotmutationinprolactinomas
_version_	1718385731016065024

Somatic SF3B1 hotspot mutation in prolactinomas

Ejemplares similares