Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known. Here, the authors show that reciprocal inhibition between Cdh1 and the c-Src signaling pathway regulate breast cancer tumorigenesis.

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Autores principales:	Tao Han, Shulong Jiang, Hong Zheng, Qing Yin, Mengyu Xie, Margaret R Little, Xiu Yin, Ming Chen, Su Jung Song, Amer A. Beg, Pier Paolo Pandolfi, Lixin Wan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0384f8d299bb452ab948ffee2b150f84
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spelling	oai:doaj.org-article:0384f8d299bb452ab948ffee2b150f842021-12-02T15:35:46ZInterplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis10.1038/s41467-019-11618-72041-1723https://doaj.org/article/0384f8d299bb452ab948ffee2b150f842019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11618-7https://doaj.org/toc/2041-1723The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known. Here, the authors show that reciprocal inhibition between Cdh1 and the c-Src signaling pathway regulate breast cancer tumorigenesis.Tao HanShulong JiangHong ZhengQing YinMengyu XieMargaret R LittleXiu YinMing ChenSu Jung SongAmer A. BegPier Paolo PandolfiLixin WanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tao Han Shulong Jiang Hong Zheng Qing Yin Mengyu Xie Margaret R Little Xiu Yin Ming Chen Su Jung Song Amer A. Beg Pier Paolo Pandolfi Lixin Wan Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
description	The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known. Here, the authors show that reciprocal inhibition between Cdh1 and the c-Src signaling pathway regulate breast cancer tumorigenesis.
format	article
author	Tao Han Shulong Jiang Hong Zheng Qing Yin Mengyu Xie Margaret R Little Xiu Yin Ming Chen Su Jung Song Amer A. Beg Pier Paolo Pandolfi Lixin Wan
author_facet	Tao Han Shulong Jiang Hong Zheng Qing Yin Mengyu Xie Margaret R Little Xiu Yin Ming Chen Su Jung Song Amer A. Beg Pier Paolo Pandolfi Lixin Wan
author_sort	Tao Han
title	Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
title_short	Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
title_full	Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
title_fullStr	Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
title_full_unstemmed	Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
title_sort	interplay between c-src and the apc/c co-activator cdh1 regulates mammary tumorigenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0384f8d299bb452ab948ffee2b150f84
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Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

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