Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity

Abstract The beneficial effects of brown adipose tissue (BAT) on obesity and associated metabolic diseases are mediated through its capacity to dissipate energy as heat. While immune cells, such as tissue-resident macrophages, are known to influence adipose tissue homeostasis, relatively little is k...

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Autores principales:	Roberto Diaz-Marin, Sergio Crespo-Garcia, Ariel M. Wilson, Manuel Buscarlet, Agnieszka Dejda, Frédérik Fournier, Rachel Juneau, Thierry Alquier, Przemyslaw Sapieha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/038531e383294c999354f1395541bdba
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spelling	oai:doaj.org-article:038531e383294c999354f1395541bdba2021-12-02T16:36:37ZMyeloid-resident neuropilin-1 influences brown adipose tissue in obesity10.1038/s41598-021-95064-w2045-2322https://doaj.org/article/038531e383294c999354f1395541bdba2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95064-whttps://doaj.org/toc/2045-2322Abstract The beneficial effects of brown adipose tissue (BAT) on obesity and associated metabolic diseases are mediated through its capacity to dissipate energy as heat. While immune cells, such as tissue-resident macrophages, are known to influence adipose tissue homeostasis, relatively little is known about their contribution to BAT function. Here we report that neuropilin-1 (NRP1), a multiligand single-pass transmembrane receptor, is highly expressed in BAT-resident macrophages. During diet-induced obesity (DIO), myeloid-resident NRP1 influences interscapular BAT mass, and consequently vascular morphology, innervation density and ultimately core body temperature during cold exposure. Thus, NRP1-expressing myeloid cells contribute to the BAT homeostasis and potentially its thermogenic function in DIO.Roberto Diaz-MarinSergio Crespo-GarciaAriel M. WilsonManuel BuscarletAgnieszka DejdaFrédérik FournierRachel JuneauThierry AlquierPrzemyslaw SapiehaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roberto Diaz-Marin Sergio Crespo-Garcia Ariel M. Wilson Manuel Buscarlet Agnieszka Dejda Frédérik Fournier Rachel Juneau Thierry Alquier Przemyslaw Sapieha Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
description	Abstract The beneficial effects of brown adipose tissue (BAT) on obesity and associated metabolic diseases are mediated through its capacity to dissipate energy as heat. While immune cells, such as tissue-resident macrophages, are known to influence adipose tissue homeostasis, relatively little is known about their contribution to BAT function. Here we report that neuropilin-1 (NRP1), a multiligand single-pass transmembrane receptor, is highly expressed in BAT-resident macrophages. During diet-induced obesity (DIO), myeloid-resident NRP1 influences interscapular BAT mass, and consequently vascular morphology, innervation density and ultimately core body temperature during cold exposure. Thus, NRP1-expressing myeloid cells contribute to the BAT homeostasis and potentially its thermogenic function in DIO.
format	article
author	Roberto Diaz-Marin Sergio Crespo-Garcia Ariel M. Wilson Manuel Buscarlet Agnieszka Dejda Frédérik Fournier Rachel Juneau Thierry Alquier Przemyslaw Sapieha
author_facet	Roberto Diaz-Marin Sergio Crespo-Garcia Ariel M. Wilson Manuel Buscarlet Agnieszka Dejda Frédérik Fournier Rachel Juneau Thierry Alquier Przemyslaw Sapieha
author_sort	Roberto Diaz-Marin
title	Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
title_short	Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
title_full	Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
title_fullStr	Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
title_full_unstemmed	Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
title_sort	myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/038531e383294c999354f1395541bdba
work_keys_str_mv	AT robertodiazmarin myeloidresidentneuropilin1influencesbrownadiposetissueinobesity AT sergiocrespogarcia myeloidresidentneuropilin1influencesbrownadiposetissueinobesity AT arielmwilson myeloidresidentneuropilin1influencesbrownadiposetissueinobesity AT manuelbuscarlet myeloidresidentneuropilin1influencesbrownadiposetissueinobesity AT agnieszkadejda myeloidresidentneuropilin1influencesbrownadiposetissueinobesity AT frederikfournier myeloidresidentneuropilin1influencesbrownadiposetissueinobesity AT racheljuneau myeloidresidentneuropilin1influencesbrownadiposetissueinobesity AT thierryalquier myeloidresidentneuropilin1influencesbrownadiposetissueinobesity AT przemyslawsapieha myeloidresidentneuropilin1influencesbrownadiposetissueinobesity
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Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity

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