Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.

Transcranial direct current stimulation (tDCS) is a safe, non-invasive technique for transiently modulating the balance of excitation and inhibition within the human brain. It has been reported that anodal tDCS can reduce both GABA mediated inhibition and GABA concentration within the human motor co...

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Autores principales:	Daniel P Spiegel, Bruce C Hansen, Winston D Byblow, Benjamin Thompson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/038c96f70617454b80493c6451fad2af
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spelling	oai:doaj.org-article:038c96f70617454b80493c6451fad2af2021-11-18T07:20:03ZAnodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.1932-620310.1371/journal.pone.0036220https://doaj.org/article/038c96f70617454b80493c6451fad2af2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22563485/?tool=EBIhttps://doaj.org/toc/1932-6203Transcranial direct current stimulation (tDCS) is a safe, non-invasive technique for transiently modulating the balance of excitation and inhibition within the human brain. It has been reported that anodal tDCS can reduce both GABA mediated inhibition and GABA concentration within the human motor cortex. As GABA mediated inhibition is thought to be a key modulator of plasticity within the adult brain, these findings have broad implications for the future use of tDCS. It is important, therefore, to establish whether tDCS can exert similar effects within non-motor brain areas. The aim of this study was to assess whether anodal tDCS could reduce inhibitory interactions within the human visual cortex. Psychophysical measures of surround suppression were used as an index of inhibition within V1. Overlay suppression, which is thought to originate within the lateral geniculate nucleus (LGN), was also measured as a control. Anodal stimulation of the occipital poles significantly reduced psychophysical surround suppression, but had no effect on overlay suppression. This effect was specific to anodal stimulation as cathodal stimulation had no effect on either measure. These psychophysical results provide the first evidence for tDCS-induced reductions of intracortical inhibition within the human visual cortex.Daniel P SpiegelBruce C HansenWinston D ByblowBenjamin ThompsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e36220 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel P Spiegel Bruce C Hansen Winston D Byblow Benjamin Thompson Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.
description	Transcranial direct current stimulation (tDCS) is a safe, non-invasive technique for transiently modulating the balance of excitation and inhibition within the human brain. It has been reported that anodal tDCS can reduce both GABA mediated inhibition and GABA concentration within the human motor cortex. As GABA mediated inhibition is thought to be a key modulator of plasticity within the adult brain, these findings have broad implications for the future use of tDCS. It is important, therefore, to establish whether tDCS can exert similar effects within non-motor brain areas. The aim of this study was to assess whether anodal tDCS could reduce inhibitory interactions within the human visual cortex. Psychophysical measures of surround suppression were used as an index of inhibition within V1. Overlay suppression, which is thought to originate within the lateral geniculate nucleus (LGN), was also measured as a control. Anodal stimulation of the occipital poles significantly reduced psychophysical surround suppression, but had no effect on overlay suppression. This effect was specific to anodal stimulation as cathodal stimulation had no effect on either measure. These psychophysical results provide the first evidence for tDCS-induced reductions of intracortical inhibition within the human visual cortex.
format	article
author	Daniel P Spiegel Bruce C Hansen Winston D Byblow Benjamin Thompson
author_facet	Daniel P Spiegel Bruce C Hansen Winston D Byblow Benjamin Thompson
author_sort	Daniel P Spiegel
title	Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.
title_short	Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.
title_full	Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.
title_fullStr	Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.
title_full_unstemmed	Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.
title_sort	anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/038c96f70617454b80493c6451fad2af
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Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.

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