Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes

Abstract To assess the optical coherence tomography (OCT) features of the repair tissue after retinal pigment epithelial (RPE) tear in neovascular age-related macular degeneration. Retrospective, observational study. Medical and imaging records of patients that developed tears after starting anti-VE...

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Autores principales:	Francesco Romano, Salvatore Parrulli, Maurizio Battaglia Parodi, Marco Lupidi, Matteo Cereda, Giovanni Staurenghi, Alessandro Invernizzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/038e6e9eb4cd40578bbea942d695e6e2
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spelling	oai:doaj.org-article:038e6e9eb4cd40578bbea942d695e6e22021-12-02T13:17:55ZOptical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes10.1038/s41598-021-85270-x2045-2322https://doaj.org/article/038e6e9eb4cd40578bbea942d695e6e22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85270-xhttps://doaj.org/toc/2045-2322Abstract To assess the optical coherence tomography (OCT) features of the repair tissue after retinal pigment epithelial (RPE) tear in neovascular age-related macular degeneration. Retrospective, observational study. Medical and imaging records of patients that developed tears after starting anti-VEGF treatment and with at least 12 months of follow-up were reviewed. OCT reflectivity of the RPE-subretinal hyperreflective tissue (SHT) complex was measured at 6, 12 and 18 months (when available). Reflectivity of the adjacent unaffected RPE-Bruch’s membrane was taken as internal reference. Other variables: grade and rip occurrence (early/late); number of intravitreal injections; type of macular neovascularization; sub-macular hemorrhage (SMH) at onset. Forty-nine eyes (age: 76.1 ± 7.0 years; VA: 0.54 ± 0.27 LogMAR) were included. Thirty-eight eyes had OCT signs of healing during the follow-up, with 21 showing SMH at baseline. Final VA positively correlated with the number of injections and negatively correlated with the RPE-SHT reflectivity and the presence of SMH (p < 0.001). Reflectivity of the RPE-SHT complex was positively associated with time and SMH at baseline (p < 0.05). In our study, most eyes showed signs of tissue repair after RPE tear. The reflectivity of repair tissue, the SMH presence and the number of anti-VEGF injections appeared to be major predictors of visual outcomes.Francesco RomanoSalvatore ParrulliMaurizio Battaglia ParodiMarco LupidiMatteo CeredaGiovanni StaurenghiAlessandro InvernizziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francesco Romano Salvatore Parrulli Maurizio Battaglia Parodi Marco Lupidi Matteo Cereda Giovanni Staurenghi Alessandro Invernizzi Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes
description	Abstract To assess the optical coherence tomography (OCT) features of the repair tissue after retinal pigment epithelial (RPE) tear in neovascular age-related macular degeneration. Retrospective, observational study. Medical and imaging records of patients that developed tears after starting anti-VEGF treatment and with at least 12 months of follow-up were reviewed. OCT reflectivity of the RPE-subretinal hyperreflective tissue (SHT) complex was measured at 6, 12 and 18 months (when available). Reflectivity of the adjacent unaffected RPE-Bruch’s membrane was taken as internal reference. Other variables: grade and rip occurrence (early/late); number of intravitreal injections; type of macular neovascularization; sub-macular hemorrhage (SMH) at onset. Forty-nine eyes (age: 76.1 ± 7.0 years; VA: 0.54 ± 0.27 LogMAR) were included. Thirty-eight eyes had OCT signs of healing during the follow-up, with 21 showing SMH at baseline. Final VA positively correlated with the number of injections and negatively correlated with the RPE-SHT reflectivity and the presence of SMH (p < 0.001). Reflectivity of the RPE-SHT complex was positively associated with time and SMH at baseline (p < 0.05). In our study, most eyes showed signs of tissue repair after RPE tear. The reflectivity of repair tissue, the SMH presence and the number of anti-VEGF injections appeared to be major predictors of visual outcomes.
format	article
author	Francesco Romano Salvatore Parrulli Maurizio Battaglia Parodi Marco Lupidi Matteo Cereda Giovanni Staurenghi Alessandro Invernizzi
author_facet	Francesco Romano Salvatore Parrulli Maurizio Battaglia Parodi Marco Lupidi Matteo Cereda Giovanni Staurenghi Alessandro Invernizzi
author_sort	Francesco Romano
title	Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes
title_short	Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes
title_full	Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes
title_fullStr	Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes
title_full_unstemmed	Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes
title_sort	optical coherence tomography features of the repair tissue following rpe tear and their correlation with visual outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/038e6e9eb4cd40578bbea942d695e6e2
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_version_	1718393310764072960

Optical coherence tomography features of the repair tissue following RPE tear and their correlation with visual outcomes

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