Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds
Abstract Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improvin...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0390bead9023420b8ec15211d1d46082 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0390bead9023420b8ec15211d1d46082 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0390bead9023420b8ec15211d1d460822021-12-02T11:41:08ZSustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds10.1038/s41598-020-76971-w2045-2322https://doaj.org/article/0390bead9023420b8ec15211d1d460822020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76971-whttps://doaj.org/toc/2045-2322Abstract Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core–shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications.Tuerdimaimaiti AbudulaKalamegam GauthamanAzadeh MostafaviAhmed AlshahrieNuman SalahPierfrancesco MorgantiAngelo ChianeseAli TamayolAdnan MemicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Tuerdimaimaiti Abudula Kalamegam Gauthaman Azadeh Mostafavi Ahmed Alshahrie Numan Salah Pierfrancesco Morganti Angelo Chianese Ali Tamayol Adnan Memic Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
| description |
Abstract Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core–shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications. |
| format |
article |
| author |
Tuerdimaimaiti Abudula Kalamegam Gauthaman Azadeh Mostafavi Ahmed Alshahrie Numan Salah Pierfrancesco Morganti Angelo Chianese Ali Tamayol Adnan Memic |
| author_facet |
Tuerdimaimaiti Abudula Kalamegam Gauthaman Azadeh Mostafavi Ahmed Alshahrie Numan Salah Pierfrancesco Morganti Angelo Chianese Ali Tamayol Adnan Memic |
| author_sort |
Tuerdimaimaiti Abudula |
| title |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
| title_short |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
| title_full |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
| title_fullStr |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
| title_full_unstemmed |
Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
| title_sort |
sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/0390bead9023420b8ec15211d1d46082 |
| work_keys_str_mv |
AT tuerdimaimaitiabudula sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds AT kalamegamgauthaman sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds AT azadehmostafavi sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds AT ahmedalshahrie sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds AT numansalah sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds AT pierfrancescomorganti sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds AT angelochianese sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds AT alitamayol sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds AT adnanmemic sustainabledrugreleasefrompolycaprolactonecoatedchitinligningelfibrousscaffolds |
| _version_ |
1718395440458629120 |