Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity

The processes regulating the ageing of stem cells are not clearly defined. Here, the authors report that in haematopoietic stem cells (HSC) thioredoxin-interacting protein, known to regulate the cell cycle, binds to p38 mitogen-activated protein kinase and regulates HSC ageing and rejuvenation.

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Autores principales:	Haiyoung Jung, Dong Oh Kim, Jae-Eun Byun, Won Sam Kim, Mi Jeong Kim, Hae Young Song, Young Kwan Kim, Du-Kyeong Kang, Young-Jun Park, Tae-Don Kim, Suk Ran Yoon, Hee Gu Lee, Eun-Ji Choi, Sang-Hyun Min, Inpyo Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0392befb4f42442f914d7b6d4d852291
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spelling	oai:doaj.org-article:0392befb4f42442f914d7b6d4d8522912021-12-02T14:39:34ZThioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity10.1038/ncomms136742041-1723https://doaj.org/article/0392befb4f42442f914d7b6d4d8522912016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13674https://doaj.org/toc/2041-1723The processes regulating the ageing of stem cells are not clearly defined. Here, the authors report that in haematopoietic stem cells (HSC) thioredoxin-interacting protein, known to regulate the cell cycle, binds to p38 mitogen-activated protein kinase and regulates HSC ageing and rejuvenation.Haiyoung JungDong Oh KimJae-Eun ByunWon Sam KimMi Jeong KimHae Young SongYoung Kwan KimDu-Kyeong KangYoung-Jun ParkTae-Don KimSuk Ran YoonHee Gu LeeEun-Ji ChoiSang-Hyun MinInpyo ChoiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haiyoung Jung Dong Oh Kim Jae-Eun Byun Won Sam Kim Mi Jeong Kim Hae Young Song Young Kwan Kim Du-Kyeong Kang Young-Jun Park Tae-Don Kim Suk Ran Yoon Hee Gu Lee Eun-Ji Choi Sang-Hyun Min Inpyo Choi Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
description	The processes regulating the ageing of stem cells are not clearly defined. Here, the authors report that in haematopoietic stem cells (HSC) thioredoxin-interacting protein, known to regulate the cell cycle, binds to p38 mitogen-activated protein kinase and regulates HSC ageing and rejuvenation.
format	article
author	Haiyoung Jung Dong Oh Kim Jae-Eun Byun Won Sam Kim Mi Jeong Kim Hae Young Song Young Kwan Kim Du-Kyeong Kang Young-Jun Park Tae-Don Kim Suk Ran Yoon Hee Gu Lee Eun-Ji Choi Sang-Hyun Min Inpyo Choi
author_facet	Haiyoung Jung Dong Oh Kim Jae-Eun Byun Won Sam Kim Mi Jeong Kim Hae Young Song Young Kwan Kim Du-Kyeong Kang Young-Jun Park Tae-Don Kim Suk Ran Yoon Hee Gu Lee Eun-Ji Choi Sang-Hyun Min Inpyo Choi
author_sort	Haiyoung Jung
title	Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
title_short	Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
title_full	Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
title_fullStr	Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
title_full_unstemmed	Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
title_sort	thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0392befb4f42442f914d7b6d4d852291
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Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity

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