Jabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes

The Brazilian berry scientifically known as jabuticaba is a fruit covered by a dark purple peel that is still rich in bioactives, especially polyphenols. Considering that, this work was aimed at obtaining an extract from the peel of jabuticaba fruits, identifying its main components, loading it in p...

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Autores principales:	Ines Castangia, Maria Letizia Manca, Mohamad Allaw, Jarkko Hellström, Daniel Granato, Maria Manconi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	reactive oxygen species circular economy bioactives phenolic compounds phospholipid vesicles wound healing Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/03938a0329d84f348a44d6fba513460e
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spelling	oai:doaj.org-article:03938a0329d84f348a44d6fba513460e2021-11-11T18:38:56ZJabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes10.3390/molecules262166971420-3049https://doaj.org/article/03938a0329d84f348a44d6fba513460e2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6697https://doaj.org/toc/1420-3049The Brazilian berry scientifically known as jabuticaba is a fruit covered by a dark purple peel that is still rich in bioactives, especially polyphenols. Considering that, this work was aimed at obtaining an extract from the peel of jabuticaba fruits, identifying its main components, loading it in phospholipid vesicles specifically tailored for skin delivery and evaluating their biological efficacy. The extract was obtained by pressurized hot water extraction (PHWE), which is considered an easy and low dissipative method, and it was rich in polyphenolic compounds, especially flavonoids (<i>ortho</i>-diphenols and condensed tannins), anthocyanins (cyanidin 3-<i>O</i>-glucoside and delphinidin 3-<i>O</i>-glucoside) and gallic acid, which were responsible for the high antioxidant activity detected using different colorimetric methods (DPPH, FRAP, CUPRAC and metal chelation). To improve the stability and extract effectiveness, it was incorporated into ultradeformable phospholipid vesicles (transfersomes) that were modified by adding two different polymers (hydroxyethyl cellulose and sodium hyaluronate), thus obtaining HEcellulose-transfersomes and hyaluronan-transfersomes. Transfersomes without polymers were the smallest, as the addition of the polymer led to the formation of larger vesicles that were more stable in storage. The incorporation of the extract in the vesicles promoted their beneficial activities as they were capable, to a greater extent than the solution used as reference, of counteracting the toxic effect of hydrogen peroxide and even of speeding up the healing of a wound performed in a cell monolayer, especially when vesicles were enriched with polymers. Given that, polymer enriched vesicles may represent a good strategy to produce cosmetical and cosmeceutical products with beneficial properties for skin.Ines CastangiaMaria Letizia MancaMohamad AllawJarkko HellströmDaniel GranatoMaria ManconiMDPI AGarticlereactive oxygen speciescircular economybioactivesphenolic compoundsphospholipid vesicleswound healingOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6697, p 6697 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reactive oxygen species circular economy bioactives phenolic compounds phospholipid vesicles wound healing Organic chemistry QD241-441
spellingShingle	reactive oxygen species circular economy bioactives phenolic compounds phospholipid vesicles wound healing Organic chemistry QD241-441 Ines Castangia Maria Letizia Manca Mohamad Allaw Jarkko Hellström Daniel Granato Maria Manconi Jabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes
description	The Brazilian berry scientifically known as jabuticaba is a fruit covered by a dark purple peel that is still rich in bioactives, especially polyphenols. Considering that, this work was aimed at obtaining an extract from the peel of jabuticaba fruits, identifying its main components, loading it in phospholipid vesicles specifically tailored for skin delivery and evaluating their biological efficacy. The extract was obtained by pressurized hot water extraction (PHWE), which is considered an easy and low dissipative method, and it was rich in polyphenolic compounds, especially flavonoids (<i>ortho</i>-diphenols and condensed tannins), anthocyanins (cyanidin 3-<i>O</i>-glucoside and delphinidin 3-<i>O</i>-glucoside) and gallic acid, which were responsible for the high antioxidant activity detected using different colorimetric methods (DPPH, FRAP, CUPRAC and metal chelation). To improve the stability and extract effectiveness, it was incorporated into ultradeformable phospholipid vesicles (transfersomes) that were modified by adding two different polymers (hydroxyethyl cellulose and sodium hyaluronate), thus obtaining HEcellulose-transfersomes and hyaluronan-transfersomes. Transfersomes without polymers were the smallest, as the addition of the polymer led to the formation of larger vesicles that were more stable in storage. The incorporation of the extract in the vesicles promoted their beneficial activities as they were capable, to a greater extent than the solution used as reference, of counteracting the toxic effect of hydrogen peroxide and even of speeding up the healing of a wound performed in a cell monolayer, especially when vesicles were enriched with polymers. Given that, polymer enriched vesicles may represent a good strategy to produce cosmetical and cosmeceutical products with beneficial properties for skin.
format	article
author	Ines Castangia Maria Letizia Manca Mohamad Allaw Jarkko Hellström Daniel Granato Maria Manconi
author_facet	Ines Castangia Maria Letizia Manca Mohamad Allaw Jarkko Hellström Daniel Granato Maria Manconi
author_sort	Ines Castangia
title	Jabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes
title_short	Jabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes
title_full	Jabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes
title_fullStr	Jabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes
title_full_unstemmed	Jabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes
title_sort	jabuticaba (<i>myrciaria jaboticaba</i>) peel as a sustainable source of anthocyanins and ellagitannins delivered by phospholipid vesicles for alleviating oxidative stress in human keratinocytes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/03938a0329d84f348a44d6fba513460e
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Jabuticaba (<i>Myrciaria jaboticaba</i>) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes

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