Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes

Ying Tang,1,2 Lilin Gong,1 Xiangjun Chen,1 Zhipeng Du,1 Jinbo Hu,1 Zhixin Xu,1 Jinshan Wu,1 Qifu Li,1 Zhihong Wang1 1Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Endocrinology, West China-G...

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Autores principales:	Tang Y, Gong L, Chen X, Du Z, Hu J, Xu Z, Wu J, Li Q, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	type 2 diabetes ageing body composition bone mineral density dual-energy x-ray absorptiometry Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0398f6c5a02f40ddbf4236b1fd33d4ed
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spelling	oai:doaj.org-article:0398f6c5a02f40ddbf4236b1fd33d4ed2021-12-02T10:48:25ZAge-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes1178-7007https://doaj.org/article/0398f6c5a02f40ddbf4236b1fd33d4ed2020-12-01T00:00:00Zhttps://www.dovepress.com/age-related-changes-in-body-composition-and-bone-mineral-density-and-t-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ying Tang,1,2 Lilin Gong,1 Xiangjun Chen,1 Zhipeng Du,1 Jinbo Hu,1 Zhixin Xu,1 Jinshan Wu,1 Qifu Li,1 Zhihong Wang1 1Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Endocrinology, West China-Guang’an Hospital, Sichuan University, Sichuan, People’s Republic of ChinaCorrespondence: Zhihong WangThe First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of ChinaTel/Fax +86-23-89011552Email towzh713@126.comPurpose: To investigate age-related changes in body composition (BC) and bone mineral density (BMD) in type 2 diabetes (T2D) and analyse whether diabetes duration or glycaemic control affects these factors.Patients and Methods: We enrolled 1474 hospitalized T2D patients (817 males and 657 females; 45– 85 years). BC and BMD were assessed by dual-energy X-ray absorptiometry (DEXA). Patients were stratified into age groups: 45– 54, 55– 64, 65– 74, and ≥ 75 years. Continuous variables were compared using t-tests or one-way analysis of variance (ANOVA), and categorical variables were compared using chi-square tests. Effects of age, diabetes duration, and haemoglobin A1C (HbA1c) on BC and BMD were assessed with multiple linear regression models.Results: In T2D, in females, changes in fat mass index (FMI) were positively correlated with age, while changes in lean mass index (LMI) were unrelated to age. Changes in FMI or LMI in males were unrelated to age. For regional BC distribution, changes in visceral adipose tissue (VAT) were positively correlated with age for both males and females, while changes in appendage lean mass (ALM) were negatively correlated with age. For BMD, changes in total BMD (TBMD) in males were not correlated with age, while changes in lumbar spine BMD (LBMD) were positively correlated with age, and femoral neck BMD (FNBMD) was negatively correlated with age. Changes in BMD in all parts of females were negatively correlated with age. In addition, changes in BC and BMD were unrelated to diabetes duration, and HbA1c was mainly associated with decreases in lean mass but had little effect on other BC and BMD parameters.Conclusion: In T2D, changes in BC and BMD were associated with age but not diabetes duration. A higher HbA1c is associated with lower lean mass.Keywords: type 2 diabetes, ageing, body composition, bone mineral density, dual-energy X-ray absorptiometryTang YGong LChen XDu ZHu JXu ZWu JLi QWang ZDove Medical Pressarticletype 2 diabetesageingbody compositionbone mineral densitydual-energy x-ray absorptiometrySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4699-4710 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes ageing body composition bone mineral density dual-energy x-ray absorptiometry Specialties of internal medicine RC581-951
spellingShingle	type 2 diabetes ageing body composition bone mineral density dual-energy x-ray absorptiometry Specialties of internal medicine RC581-951 Tang Y Gong L Chen X Du Z Hu J Xu Z Wu J Li Q Wang Z Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes
description	Ying Tang,1,2 Lilin Gong,1 Xiangjun Chen,1 Zhipeng Du,1 Jinbo Hu,1 Zhixin Xu,1 Jinshan Wu,1 Qifu Li,1 Zhihong Wang1 1Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Endocrinology, West China-Guang’an Hospital, Sichuan University, Sichuan, People’s Republic of ChinaCorrespondence: Zhihong WangThe First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of ChinaTel/Fax +86-23-89011552Email towzh713@126.comPurpose: To investigate age-related changes in body composition (BC) and bone mineral density (BMD) in type 2 diabetes (T2D) and analyse whether diabetes duration or glycaemic control affects these factors.Patients and Methods: We enrolled 1474 hospitalized T2D patients (817 males and 657 females; 45– 85 years). BC and BMD were assessed by dual-energy X-ray absorptiometry (DEXA). Patients were stratified into age groups: 45– 54, 55– 64, 65– 74, and ≥ 75 years. Continuous variables were compared using t-tests or one-way analysis of variance (ANOVA), and categorical variables were compared using chi-square tests. Effects of age, diabetes duration, and haemoglobin A1C (HbA1c) on BC and BMD were assessed with multiple linear regression models.Results: In T2D, in females, changes in fat mass index (FMI) were positively correlated with age, while changes in lean mass index (LMI) were unrelated to age. Changes in FMI or LMI in males were unrelated to age. For regional BC distribution, changes in visceral adipose tissue (VAT) were positively correlated with age for both males and females, while changes in appendage lean mass (ALM) were negatively correlated with age. For BMD, changes in total BMD (TBMD) in males were not correlated with age, while changes in lumbar spine BMD (LBMD) were positively correlated with age, and femoral neck BMD (FNBMD) was negatively correlated with age. Changes in BMD in all parts of females were negatively correlated with age. In addition, changes in BC and BMD were unrelated to diabetes duration, and HbA1c was mainly associated with decreases in lean mass but had little effect on other BC and BMD parameters.Conclusion: In T2D, changes in BC and BMD were associated with age but not diabetes duration. A higher HbA1c is associated with lower lean mass.Keywords: type 2 diabetes, ageing, body composition, bone mineral density, dual-energy X-ray absorptiometry
format	article
author	Tang Y Gong L Chen X Du Z Hu J Xu Z Wu J Li Q Wang Z
author_facet	Tang Y Gong L Chen X Du Z Hu J Xu Z Wu J Li Q Wang Z
author_sort	Tang Y
title	Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes
title_short	Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes
title_full	Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes
title_fullStr	Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes
title_full_unstemmed	Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes
title_sort	age-related changes in body composition and bone mineral density and their relationship with the duration of diabetes and glycaemic control in type 2 diabetes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0398f6c5a02f40ddbf4236b1fd33d4ed
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Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes

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