Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage

Yong Cai,1 Yao-Kun Zhuang,1 Xiao-Yu Wu,1 Xiao-Qiao Dong,2 Quan Du,2 Wen-Hua Yu,2 Ke-Yi Wang,2 Wei Hu,3 Yong-Ke Zheng3 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, People’s Republic of China; 2Department of Neurosurgery, Affiliated...

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Autores principales:	Cai Y, Zhuang YK, Wu XY, Dong XQ, Du Q, Yu WH, Wang KY, Hu W, Zheng YK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	intracerebral hemorrhage prognosis severity hypoxia-inducible factor 1alpha Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/039ce7b809c348b99aef8686249d47ff
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spelling	oai:doaj.org-article:039ce7b809c348b99aef8686249d47ff2021-12-02T18:31:00ZSerum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage1178-203Xhttps://doaj.org/article/039ce7b809c348b99aef8686249d47ff2021-07-01T00:00:00Zhttps://www.dovepress.com/serum-hypoxia-inducible-factor-1alpha-levels-correlate-with-outcomes-a-peer-reviewed-fulltext-article-TCRMhttps://doaj.org/toc/1178-203XYong Cai,1 Yao-Kun Zhuang,1 Xiao-Yu Wu,1 Xiao-Qiao Dong,2 Quan Du,2 Wen-Hua Yu,2 Ke-Yi Wang,2 Wei Hu,3 Yong-Ke Zheng3 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, People’s Republic of China; 2Department of Neurosurgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, People’s Republic of China; 3Department of Intensive Care Unit, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, People’s Republic of ChinaCorrespondence: Xiao-Qiao DongDepartment of Neurosurgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 261 Huansha Road, Hangzhou, 310006, Zhejiang Province, People’s Republic of ChinaEmail dxqhyy@163.comBackground: Serum hypoxia-inducible factor 1alpha (HIF-1α) is a key regulator in hypoxic and ischemic brain injury. We determined the relationship between serum HIF-1α levels and long-term prognosis plus severity of intracerebral hemorrhage (ICH).Methods: A total of 97 ICH cases and 97 healthy controls were enrolled. Glasgow Coma Scale (GCS) score and hematoma volume were used to assess hemorrhagic severity. Glasgow Outcome Scale (GOS) score of 1– 3 at post-stroke 90 days was defined as a poor outcome.Results: Serum HIF-1α levels of ICH patients were significantly higher than those of healthy controls (median, 218.8 vs 105.4 pg/mL; P< 0.001) and were substantially correlated with GCS score (r=− 0.485, P< 0.001), hematoma volume (r=0.357, P< 0.001) and GOS score (r=− 0.436, P< 0.001). Serum HIF-1α levels > 239.4 pg/mL discriminated patients at risk of 90-day poor outcome with sensitivity of 65.9% and specificity of 79.3% (area under the receiver operating characteristic curve, 0.725; 95% confidence interval, 0.625– 0.811; P< 0.001). Moreover, serum HIF-1α levels > 239.4 pg/mL were independently associated with a poor 90-day outcome (odds ratio, 5.133; 95% confidence interval, 1.117– 23.593; P=0.036).Conclusion: Serum HIF-1α, in close correlation with hemorrhagic severity and poor 90-day outcome, may serve as a potential prognostic biomarker for ICH.Keywords: intracerebral hemorrhage, prognosis, severity, hypoxia-inducible factor 1alphaCai YZhuang YKWu XYDong XQDu QYu WHWang KYHu WZheng YKDove Medical Pressarticleintracerebral hemorrhageprognosisseverityhypoxia-inducible factor 1alphaTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 717-726 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intracerebral hemorrhage prognosis severity hypoxia-inducible factor 1alpha Therapeutics. Pharmacology RM1-950
spellingShingle	intracerebral hemorrhage prognosis severity hypoxia-inducible factor 1alpha Therapeutics. Pharmacology RM1-950 Cai Y Zhuang YK Wu XY Dong XQ Du Q Yu WH Wang KY Hu W Zheng YK Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage
description	Yong Cai,1 Yao-Kun Zhuang,1 Xiao-Yu Wu,1 Xiao-Qiao Dong,2 Quan Du,2 Wen-Hua Yu,2 Ke-Yi Wang,2 Wei Hu,3 Yong-Ke Zheng3 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, People’s Republic of China; 2Department of Neurosurgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, People’s Republic of China; 3Department of Intensive Care Unit, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang Province, People’s Republic of ChinaCorrespondence: Xiao-Qiao DongDepartment of Neurosurgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 261 Huansha Road, Hangzhou, 310006, Zhejiang Province, People’s Republic of ChinaEmail dxqhyy@163.comBackground: Serum hypoxia-inducible factor 1alpha (HIF-1α) is a key regulator in hypoxic and ischemic brain injury. We determined the relationship between serum HIF-1α levels and long-term prognosis plus severity of intracerebral hemorrhage (ICH).Methods: A total of 97 ICH cases and 97 healthy controls were enrolled. Glasgow Coma Scale (GCS) score and hematoma volume were used to assess hemorrhagic severity. Glasgow Outcome Scale (GOS) score of 1– 3 at post-stroke 90 days was defined as a poor outcome.Results: Serum HIF-1α levels of ICH patients were significantly higher than those of healthy controls (median, 218.8 vs 105.4 pg/mL; P< 0.001) and were substantially correlated with GCS score (r=− 0.485, P< 0.001), hematoma volume (r=0.357, P< 0.001) and GOS score (r=− 0.436, P< 0.001). Serum HIF-1α levels > 239.4 pg/mL discriminated patients at risk of 90-day poor outcome with sensitivity of 65.9% and specificity of 79.3% (area under the receiver operating characteristic curve, 0.725; 95% confidence interval, 0.625– 0.811; P< 0.001). Moreover, serum HIF-1α levels > 239.4 pg/mL were independently associated with a poor 90-day outcome (odds ratio, 5.133; 95% confidence interval, 1.117– 23.593; P=0.036).Conclusion: Serum HIF-1α, in close correlation with hemorrhagic severity and poor 90-day outcome, may serve as a potential prognostic biomarker for ICH.Keywords: intracerebral hemorrhage, prognosis, severity, hypoxia-inducible factor 1alpha
format	article
author	Cai Y Zhuang YK Wu XY Dong XQ Du Q Yu WH Wang KY Hu W Zheng YK
author_facet	Cai Y Zhuang YK Wu XY Dong XQ Du Q Yu WH Wang KY Hu W Zheng YK
author_sort	Cai Y
title	Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage
title_short	Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage
title_full	Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage
title_fullStr	Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage
title_full_unstemmed	Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage
title_sort	serum hypoxia-inducible factor 1alpha levels correlate with outcomes after intracerebral hemorrhage
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/039ce7b809c348b99aef8686249d47ff
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Serum Hypoxia-Inducible Factor 1alpha Levels Correlate with Outcomes After Intracerebral Hemorrhage

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