Factors associated with quality of life in Italian children and adolescents with IBD

Abstract Improving the quality of life (QoL) is crucial in the management of pediatric inflammatory bowel disease (IBD). We aimed to (1) Validate the IMPACT-III questionnaire in Italian IBD children; (2) explore factors associated to QoL in pediatric IBD. Internal consistency, concurrent validity, d...

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Autores principales:	Simona Gatti, Giada Del Baldo, Giulia Catassi, Andrea Faragalli, Marina Aloi, Matteo Bramuzzo, Giulia D’Arcangelo, Enrico Felici, Maurizio Fuoti, Sara Lega, Roberto Panceri, Maria Pastore, Francesca Penagini, Rosaria Gesuita, Carlo Catassi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/039d18acdee84278b78726da4b824885
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spelling	oai:doaj.org-article:039d18acdee84278b78726da4b8248852021-12-02T18:03:05ZFactors associated with quality of life in Italian children and adolescents with IBD10.1038/s41598-021-97661-12045-2322https://doaj.org/article/039d18acdee84278b78726da4b8248852021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97661-1https://doaj.org/toc/2045-2322Abstract Improving the quality of life (QoL) is crucial in the management of pediatric inflammatory bowel disease (IBD). We aimed to (1) Validate the IMPACT-III questionnaire in Italian IBD children; (2) explore factors associated to QoL in pediatric IBD. Internal consistency, concurrent validity, discriminant validity and reproducibility of the Italian version of the IMPACT-III questionnaire was measured in IBD children/adolescents in 8 centers. Associations between patient and disease characteristics and the IMPACT-III domains were analyzed through quantile regression analysis. The IMPACT-III questionnaire, collected in 282 children with IBD (median age: 14.8 years; IQR 12.4–16.4) showed a median total score of 76 (IQR 67–83). Female gender, active disease and age were negatively associated with the total IMPACT-III score. Specifically, female gender was negatively associated with the Bowel/Systemic Symptoms, Emotional and Treatment domain scores, while disease activity was significantly associated with Bowel Symptoms and Treatment/Interventions reported QoL. The IMPACT- III showed good internal consistency (Cronbach’s alpha coefficient = 0.87, 95% CI 0.85–0.89) and reproducibility (Concordance Correlation Coefficient = 0.66, 95% CI 0.57–0.74). In Italian children with IBD active disease, female gender and adolescence are associated to a worse QoL, indicating the need of more attention in this subgroup of young patients. IMPACT-III questionnaire is a reliable instrument to measure QoL in Italian children.Simona GattiGiada Del BaldoGiulia CatassiAndrea FaragalliMarina AloiMatteo BramuzzoGiulia D’ArcangeloEnrico FeliciMaurizio FuotiSara LegaRoberto PanceriMaria PastoreFrancesca PenaginiRosaria GesuitaCarlo CatassiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simona Gatti Giada Del Baldo Giulia Catassi Andrea Faragalli Marina Aloi Matteo Bramuzzo Giulia D’Arcangelo Enrico Felici Maurizio Fuoti Sara Lega Roberto Panceri Maria Pastore Francesca Penagini Rosaria Gesuita Carlo Catassi Factors associated with quality of life in Italian children and adolescents with IBD
description	Abstract Improving the quality of life (QoL) is crucial in the management of pediatric inflammatory bowel disease (IBD). We aimed to (1) Validate the IMPACT-III questionnaire in Italian IBD children; (2) explore factors associated to QoL in pediatric IBD. Internal consistency, concurrent validity, discriminant validity and reproducibility of the Italian version of the IMPACT-III questionnaire was measured in IBD children/adolescents in 8 centers. Associations between patient and disease characteristics and the IMPACT-III domains were analyzed through quantile regression analysis. The IMPACT-III questionnaire, collected in 282 children with IBD (median age: 14.8 years; IQR 12.4–16.4) showed a median total score of 76 (IQR 67–83). Female gender, active disease and age were negatively associated with the total IMPACT-III score. Specifically, female gender was negatively associated with the Bowel/Systemic Symptoms, Emotional and Treatment domain scores, while disease activity was significantly associated with Bowel Symptoms and Treatment/Interventions reported QoL. The IMPACT- III showed good internal consistency (Cronbach’s alpha coefficient = 0.87, 95% CI 0.85–0.89) and reproducibility (Concordance Correlation Coefficient = 0.66, 95% CI 0.57–0.74). In Italian children with IBD active disease, female gender and adolescence are associated to a worse QoL, indicating the need of more attention in this subgroup of young patients. IMPACT-III questionnaire is a reliable instrument to measure QoL in Italian children.
format	article
author	Simona Gatti Giada Del Baldo Giulia Catassi Andrea Faragalli Marina Aloi Matteo Bramuzzo Giulia D’Arcangelo Enrico Felici Maurizio Fuoti Sara Lega Roberto Panceri Maria Pastore Francesca Penagini Rosaria Gesuita Carlo Catassi
author_facet	Simona Gatti Giada Del Baldo Giulia Catassi Andrea Faragalli Marina Aloi Matteo Bramuzzo Giulia D’Arcangelo Enrico Felici Maurizio Fuoti Sara Lega Roberto Panceri Maria Pastore Francesca Penagini Rosaria Gesuita Carlo Catassi
author_sort	Simona Gatti
title	Factors associated with quality of life in Italian children and adolescents with IBD
title_short	Factors associated with quality of life in Italian children and adolescents with IBD
title_full	Factors associated with quality of life in Italian children and adolescents with IBD
title_fullStr	Factors associated with quality of life in Italian children and adolescents with IBD
title_full_unstemmed	Factors associated with quality of life in Italian children and adolescents with IBD
title_sort	factors associated with quality of life in italian children and adolescents with ibd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/039d18acdee84278b78726da4b824885
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Factors associated with quality of life in Italian children and adolescents with IBD

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